{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T18:12:34Z","timestamp":1778091154203,"version":"3.51.4"},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Chemical Record"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>The present review outlines the latest advances in bio\u2010organometallic ferrocene chemistry carried out on the brain. The brain has emerged as a key target and model for iron\u2010loading by bioactive ferrocene\u2010based compounds. This review focuses on the in vivo, ex vivo, and in vitro experimental data using ferrocene compounds in the brain, and discusses recent findings regarding their mechanisms of action. It also provides an overview of the biomedical aspects of studying ferrocene derivatives. The objective of this mini\u2010review is to show the potential of ferrocene\u2010modified compounds for studying brain challenges.<\/jats:p>","DOI":"10.1002\/tcr.202500242","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T08:16:27Z","timestamp":1763540187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Brain as a Key Target and a Model for Iron\u2010Loading by Bioactive Ferrocene\u2010Based Compounds. Mini\u2010Review"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9227-2326","authenticated-orcid":false,"given":"Lubov V.","family":"Snegur","sequence":"first","affiliation":[{"name":"A.N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences  Moscow Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112109"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111791"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.3664"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.139589"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.Chempr.2019.10.013"},{"key":"e_1_2_9_7_1","volume-title":"Hand Book on the Toxicology of Metals","author":"Ponka P.","year":"2007"},{"key":"e_1_2_9_8_1","unstructured":"L. A.Day US Patent 3109852 (1963)."},{"key":"e_1_2_9_9_1","unstructured":"A. N.Nesmeyanov L. G.Bogomolova N. S.Kochetkova et al. USSR Patent 263807 (1966)."},{"key":"e_1_2_9_10_1","unstructured":"J. E.Robertson US Patent 3377248 (1968)."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2010.139"},{"key":"e_1_2_9_12_1","first-page":"40","article-title":"An Exploratory Study of Fe59\u2010Labeled Ferrocene as a Carrier in Tracer Techniques","volume":"5","author":"Dratz A. F.","year":"1964","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200900157"},{"key":"e_1_2_9_14_1","unstructured":"R.Lattrell H.Kief andH.Bahr Ferrocene Derivatives US Patent 4141991 (1977).https:\/\/patents.google.com\/patent\/US4141991A."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026623666230228153114"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2011183207"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CB00123J"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.216300"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00771574"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/222385a0"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910404"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00390"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065\u2010015\u20109292\u2010y"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(14)70117\u20106"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137267"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2018.05.004"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010023\u201002399\u2010z"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1537"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102433"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4CS01216J"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2020.213658"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2DT00903J"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/inorganics10120226"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2021.109044"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28155765"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15082044"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005\u20102736(75)90347\u20108"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11172\u2010017\u20101711\u20101"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.5276"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896\u20106273(00)80987\u20103"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/361031a0"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelechem.2004.04.019"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.05.062"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432\u20101033.1991.tb16389.x"},{"key":"e_1_2_9_45_1","unstructured":"H.Bahr H.Kief andR.Lattrell 3.5.5\u2010Trimethylhexanoylferrocene Process for its Preparation and Pharmaceutical Preparations DE Patent 2623486C2 (1976)."},{"key":"e_1_2_9_46_1","unstructured":"R.Lattrell H.Kief andH.Bahr 3 5 5\u2010Trimethylhexanoyl Ferrocene US Patent 4118509 (1978).https:\/\/www.freepatentsonline.com\/4118509.html."},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20102952(93)90074\u20107"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0742\u20108413(93)90158\u2010H"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090\u20109556(24)15286\u20105"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20102952(94)00521\u2010M"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010017\u20101565\u20101"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1385\/bter:86:1:73"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.20170"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36410"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00969"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20416"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097\u20104547(19990315)55:6<674::aid\u2010jnr3>3.0.co;2\u2010j"},{"key":"e_1_2_9_58_1","first-page":"1","article-title":"Microglia: The Brains First Responders","volume":"11","author":"Bilbo S. D.","year":"2017","journal-title":"Cerebrum"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/165482"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2017.08.004"}],"container-title":["The Chemical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tcr.202500242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/tcr.202500242","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tcr.202500242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T02:50:58Z","timestamp":1773024658000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tcr.202500242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,19]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/tcr.202500242"],"URL":"https:\/\/doi.org\/10.1002\/tcr.202500242","archive":["Portico"],"relation":{},"ISSN":["1527-8999","1528-0691"],"issn-type":[{"value":"1527-8999","type":"print"},{"value":"1528-0691","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,19]]},"assertion":[{"value":"2025-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500242"}}