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This review comprehensively scrutinizes recent advancements in CO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010involved multicomponent reactions with isocyanides, primarily focusing on two innovative methodologies: first, the strategic in\u2009situ generation of reactive carbonate intermediates from CO\n                    <jats:sub>2<\/jats:sub>\n                    in Ugi and Passerini reactions, which facilitates the efficient assembly of nitrogen\u2010containing fine chemicals. Second, the transition\u2010metal\u2010catalyzed direct incorporation of CO\n                    <jats:sub>2<\/jats:sub>\n                    into isocyanides, enabling subsequent cyclization with\n                    <jats:italic>o<\/jats:italic>\n                    \u2010haloanilines, alkynes, and other components to obtain privileged heterocyclic structures\u2014such as quinazolinediones and phthalimides\u2014and functional polymeric materials. These developments not only lay the fundamental mechanistic groundwork for CO\n                    <jats:sub>2<\/jats:sub>\n                    participation in amphiphilic reaction systems but also highlight its significant potential for the design of novel pharmacologically active agents and advanced functional materials.\n                  <\/jats:p>","DOI":"10.1002\/tcr.202500317","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T07:38:31Z","timestamp":1770017911000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multicomponent Reactions Involving Carbon Dioxide (CO\n                    <sub>2<\/sub>\n                    ) and Isocyanides"],"prefix":"10.1002","volume":"26","author":[{"given":"Yi\u2010Ming","family":"Chen","sequence":"first","affiliation":[{"name":"College of Pharmacy Chongqing University of Arts and Sciences  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Yu","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chongqing University of Arts and Sciences  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7483-8695","authenticated-orcid":false,"given":"Xue","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chongqing University of Arts and Sciences  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0190-1313","authenticated-orcid":false,"given":"Zhi\u2010Gang","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chongqing University of Arts and Sciences  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/catal13121489"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201906140"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.201403323"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0cs00129e"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27030787"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.231263"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b05279"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201000723"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00514"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00047J"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29133152"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1872-2067(21)64029-9"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.4c00417"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b01871"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201602095"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570179418666211022160149"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201704286"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo5017053"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol500403x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2010.06.131"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo971463z"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)00053-8"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076581"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CC04597H"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202002367"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5PY00424A"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201400385"},{"key":"e_1_2_10_29_1","first-page":"126","article-title":"Isonitriles. 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