{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T07:06:14Z","timestamp":1788937574106,"version":"build-2803163510"},"reference-count":157,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Chemical Record"],"abstract":"<jats:p>The benzopyran scaffold is a versatile family of heterocycles found in a wide range of bioactive natural products and functional molecules. In response to increasing environmental and regulatory demands, developing synthetic strategies focused on sustainability and low\u2010impact conditions has become a central focus in modern heterocyclic chemistry. Therefore, this review provides a comprehensive and critical analysis of low\u2010impact methods reported over the past 8 years for constructing benzopyran\u2010derived structures, including coumarins, flavones, chromones, chromenes, and chromanes. We systematically integrated both enabling technologies (e.g., microwave irradiation, visible\u2010light photocatalysis, continuous\u2010flow systems, and ultrasound activation) and chemical strategies involving biocatalysis, multicomponent reactions, recyclable heterogeneous catalysis, and alternative solvents, including deep eutectic solvents and ionic liquids. Advances in selectivity, efficiency, and catalyst reusability are highlighted, as are certain limitations. By contextualizing these methods within the various benzopyran scaffolds, this review provides an important foundation for the rational integration of sustainable tools in benzopyran synthesis and highlights perspectives for future research, thereby enhancing their industrial and pharmaceutical relevance.<\/jats:p>","DOI":"10.1002\/tcr.70219","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:06:46Z","timestamp":1788934006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in Unconventional and Sustainable Synthetic Approaches to Benzopyran Scaffolds"],"prefix":"10.1002","author":[{"given":"Nathalia B.","family":"S\u00e1","sequence":"first","affiliation":[{"name":"SupraSelen Laboratory Department of Organic Chemistry Universidade Federal Fluminense  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick C.","family":"Nobre","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Universidade do Estado do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelly O.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"SupraSelen Laboratory Department of Organic Chemistry Universidade Federal Fluminense  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliano B.","family":"Azeredo","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences Universidade Federal do Pampa  Uruguaiana Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9413-7638","authenticated-orcid":false,"given":"Vanessa","family":"Nascimento","sequence":"additional","affiliation":[{"name":"SupraSelen Laboratory Department of Organic Chemistry Universidade Federal Fluminense  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"276","article-title":"A Brief Review: Some Interesting Methods of Synthesis Chromene Derivatives as Bioactive Molecules","volume":"36","author":"Abdulsahib Z. 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