{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:15:55Z","timestamp":1788243355194,"version":"build-2803163510"},"reference-count":91,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Chemical Record"],"abstract":"<jats:p>\n                    The [5\u2009+\u20091] annulation is a highly efficient strategy for constructing six\u2010membered carbocycles, heterocycles, and spiro\/fused ring skeletons, playing a crucial role in the synthesis of natural products, pharmaceuticals, and functional molecules. Traditional transition\u2010metal\u2010catalyzed methods often suffer from limitations such as metal contamination, high costs, and tedious workup procedures. In contrast, base\u2010mediated\/catalyzed systems have emerged as a prominent research hotspot owing to their metal\u2010free nature, mild conditions, excellent functional group tolerance, and green economy. This review systematically summarizes the recent advances in base\u2010mediated [5\u2009+\u20091] cycloadditions over the past two decades. Based on the catalytic systems, the reactions are categorized into organic bases (tertiary amines,\n                    <jats:italic>N<\/jats:italic>\n                    \u2010heterocyclic carbenes, organophosphines) and inorganic bases (potassium\n                    <jats:italic>tert<\/jats:italic>\n                    \u2010butoxide, carbonates, and potassium methoxide). The cyclization modes involving various five\u2010atom synthons with one\u2010carbon\/one\u2010nitrogen synthons are discussed in detail. This review aims to provide a comprehensive theoretical reference for the future design of novel base\u2010mediated cycloadditions and the construction of complex cyclic pharmaceutical skeletons.\n                  <\/jats:p>","DOI":"10.1002\/tcr.70243","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:52:25Z","timestamp":1788241945000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recent Advances in Base\u2010Mediated [5\u2009+\u20091] Annulation Reactions"],"prefix":"10.1002","author":[{"given":"Yao","family":"Jiang","sequence":"first","affiliation":[{"name":"College of Advanced Interdisciplinary Science and Technology Henan University of Technology  Zhengzhou 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