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Therefore, rapid and accurate A\u03b2 detection is essential for early AD diagnosis and therapeutic monitoring. Biosensors have emerged as promising analytical tools owing to their simplicity, low cost, high sensitivity, and selectivity. In particular, metal\u2010organic frameworks, covalent organic frameworks, hydrogen\u2010bonded organic frameworks, and MXenes offer unique structural and functional advantages for A\u03b2 sensing. This review summarizes recent advances in A\u03b2 biosensors based on these materials, with emphasis on comparative analytical performance across electrochemical, optical, photoelectrochemical, and dual\u2010mode platforms. Current challenges, including matrix interference, limited discrimination of A\u03b2 isoforms, and biosensor miniaturization, are discussed. 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