{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:55:34Z","timestamp":1767916534458,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,10,23]],"date-time":"2002-10-23T00:00:00Z","timestamp":1035331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nuevo Le\u00f3n is a state in northeastern Mexico, near the border of Texas. Mean mortality rate from 1996\u201398 due to anencephaly cases was 0.6\/1,000. In 1999 a surveillance program for the registry and prevention of neural tube defects (NTD) cases was initiated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases were obtained from hospitals and OB\u2010GYN clinics by immediate notification, death certificates, or fetal death registries. Only isolated cases of NTD were included. In August 1999 a folic acid campaign was initiated with the free distribution of the vitamin to low\u2010income women with a recommendation to take a 5.0\u2010mg pill once a week. Number of cases and rates from 1999 to 2001 were compared (\u03c7<jats:sup>2<\/jats:sup> test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 2 years there has been a significant reduction in the number of cases and rates. In 1999 there were 95 NTD cases and in the years 2000 and 2001 there were only 59 and 55 respectively (<jats:italic>P<\/jats:italic> &lt; 0.001). NTD rate decreased from 1.04\/1,000 in 1999 to 0.58\/1,000 in 2001. Anencephaly and spina bifida rates decreased from 0.55\/1,000 to 0.29\/1,000 and from 0.47\/1,000 to 0.22\/1,000 respectively, from 1999\u20132001. Decrease of female cases was higher than male cases for both phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After 2 years there was a 50% decrease in the incidence of anencephaly and spina bifida cases with a significant reduction of infant mortality and disability. These results encourage us to propose the use of a single tablet of 5.0\u2010mg of folic acid per week as an alternative to supplementation on a daily basis. Teratology 66:249\u2013256, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/tera.10094","type":"journal-article","created":{"date-parts":[[2002,10,24]],"date-time":"2002-10-24T13:04:06Z","timestamp":1035464646000},"page":"249-256","source":"Crossref","is-referenced-by-count":46,"title":["Decline of neural tube defects cases after a folic acid campaign in Nuevo Le\u00f3n, M\u00e9xico"],"prefix":"10.1002","volume":"66","author":[{"given":"Laura","family":"Mart\u00ednez de Villarreal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas Z. 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