{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T12:44:26Z","timestamp":1770554666771,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,10,23]],"date-time":"2002-10-23T00:00:00Z","timestamp":1035331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The period of neurogenesis represents a window of susceptibility for in utero methylmercury (MeHg) exposure. This study examined the toxicokinetics of potentially neurotoxic doses of MeHg during neurogenesis in the developing rat to provide additional information in the areas of mercury speciation and inter\u2010study variability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pregnant Sprague\u2010Dawley rats were dosed s.c. with 5\u201322 mg\/kg MeHg on Day 11 of gestation to target rapidly dividing cells of the developing midbrain. Maternal liver, kidney, skin, blood, placenta, and the embryonic body and brain were evaluated for total and inorganic mercury content at 24, 48, and 72 hr after dosing. Tissue Hg partitioning ratios derived from our data were then compared to those derived from previous studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mercury was present in all tissues examined by 24 hr after dosing, and levels remained relatively stable over the subsequent 2 days in most tissues. The exceptions were the maternal blood and kidney, in which total mercury decreased significantly over the three days after dosing. Inorganic mercury concentrations were similarly stable over time. At maternal MeHg doses above 12 mg\/kg, non\u2010linearities were observed in mercury accumulation in the embryo, placenta and maternal liver. The mercury tissue partitioning coefficients ranged from 0.09 for maternal blood:embryo to 1.97 for maternal blood:kidney.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our observations at the 5 mg\/kg dose were consistent with those of previous studies that involved evaluations at slightly later gestational times. The estimates of tissue partitioning coefficients we derived using multiple studies provide valuable insight into the effects of inter\u2010study variability. Teratology 66:235\u2013241, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/tera.10098","type":"journal-article","created":{"date-parts":[[2002,10,24]],"date-time":"2002-10-24T13:04:06Z","timestamp":1035464646000},"page":"235-241","source":"Crossref","is-referenced-by-count":20,"title":["Methylmercury distribution in the pregnant rat and embryo during early midbrain organogenesis"],"prefix":"10.1002","volume":"66","author":[{"given":"T.A.","family":"Lewandowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.H.","family":"Pierce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.D.","family":"Pingree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.M.","family":"Faustman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,10,23]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1976.tb03181.x"},{"key":"e_1_2_1_3_1","volume-title":"Toxicological profile for mercury (update)","author":"Agency for Toxic Substances and Disease Registry","year":"1999"},{"key":"e_1_2_1_4_1","first-page":"1070","article-title":"Perinatal methylmercury poisoning in Iraq","volume":"130","author":"Amin\u2010Zaki L","year":"1976","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420380207"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/17.2.87"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.181.4096.230"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7063871"},{"key":"e_1_2_1_9_1","first-page":"G435","article-title":"Biliary transport of glutathione and methylmercury","volume":"244","author":"Ballatori N","year":"1983","journal-title":"Am J Physiol"},{"key":"e_1_2_1_10_1","first-page":"15","article-title":"Vulnerable processes of nervous system development: a review of markers and methods","volume":"21","author":"Barone S","year":"2000","journal-title":"Neurotoxicology"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(84)90071-1"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(77)90049-4"},{"key":"e_1_2_1_13_1","volume-title":"Toxicity of metals","author":"Chang LW","year":"1996"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420200107"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00293454"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197811000-00001"},{"key":"e_1_2_1_17_1","first-page":"2065","article-title":"Nutrient transport and the blood\u2010brain barrier in developing animals","volume":"45","author":"Cornford EM","year":"1986","journal-title":"Fed Proc"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/an9941902481"},{"key":"e_1_2_1_19_1","first-page":"102","article-title":"Fetotoxicity of inorganic mercury in the mouse: distribution and effects on nutrient uptake by placenta and fetus","volume":"5","author":"Danielsson BR","year":"1984","journal-title":"Biol Res Pregnancy Perinatol"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(94)90033-7"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420180310"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000145084"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-147-38315"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00307699"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408449509089885"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287398609530940"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)01964-8"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287399509532005"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(77)90035-0"},{"key":"e_1_2_1_30_1","volume-title":"The toxicity of methyl mercury","author":"Magos L","year":"1987"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(74)90220-8"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/50.1.106"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(73)90028-3"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(77)90159-4"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.00108s3511"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.761879"},{"key":"e_1_2_1_37_1","first-page":"379","article-title":"Mitotic arrest in the developing CNS after prenatal exposure to methylmercury","volume":"6","author":"Rodier PM","year":"1984","journal-title":"Neurobehav Toxicol Teratol"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(82)90152-2"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(84)90170-6"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(83)90167-6"},{"key":"e_1_2_1_41_1","first-page":"769","article-title":"Pathologic observations of the Minamata disease","volume":"9","author":"Takeuchi T","year":"1959","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_1_42_1","first-page":"69","article-title":"Pathology of fetal Minamata disease: the effect of methylmercury on human interuterine life","volume":"6","author":"Takeuchi T","year":"1977","journal-title":"Pediatrician"},{"key":"e_1_2_1_43_1","first-page":"1","article-title":"Neuropathology of childhood cases of methylmercury poisoning (Minamata disease) with prolonged symptoms, with particular reference to the decortication syndrome","volume":"1","author":"Takeuchi T","year":"1979","journal-title":"Neurotoxicology"},{"key":"e_1_2_1_44_1","volume-title":"Minamata disease","author":"Tsubaki T","year":"1977"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1976.tb03123.x"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-141-36920"},{"key":"e_1_2_1_47_1","first-page":"135","article-title":"Maternal\u2010fetal transfer of metallic mercury via the placenta and milk","volume":"27","author":"Yang Y","year":"1997","journal-title":"Ann Clin Lab Sci"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.10098","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.10098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T12:17:35Z","timestamp":1700309855000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.10098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10,23]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1002\/tera.10098"],"URL":"https:\/\/doi.org\/10.1002\/tera.10098","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,10,23]]}}}