{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:28:49Z","timestamp":1777951729895,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,5]],"date-time":"2005-05-05T00:00:00Z","timestamp":1115251200000},"content-version":"vor","delay-in-days":13518,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1968,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of acetylsalicylic acid, meclizine hydrochloride, methamphetamine hydrochloride, clomiphene citrate, vincristine sulfate, and 6\u2010aminonicotinamide on fetal development of the <jats:italic>Macaca mulatta<\/jats:italic> were studied.<\/jats:p><jats:p>Two monkeys administered acetylsalicylic acid 40 mg\/kg\/day from the 25th day of gestation to term produced normal young. Seven pregnant monkeys given meclizine hydrochloride 10 mg\/kg\/day during various five\u2010day intervals had normal progeny. Five monkeys given methamphetamine hydrochloride 0.5 mg\/kg\/day from implantation to term had four normal young and one abortion. Clomiphene citrate administered to 18 pregnant monkeys during various stages of organogenesis resulted in 16 normal offspring and two stillbirths.<\/jats:p><jats:p>Two of the five monkeys that received vincristine sulfate produced offspring with congenital malformations. One, given a single injection of 0.175 mg\/kg on the twenty\u2010ninth day of gestation, had an offspring with encephalocele. One administration of 0.15 mg\/kg on the twenty\u2010seventh day of gestation produced syndactyly in the offspring of another. The other monkeys, which received 0.15 or 0.20 mg\/kg on the twenty\u2010eighth, thirty\u2010third, or thirty\u2010fourth day of gestation, produced normal offspring.<\/jats:p><jats:p>Seven monkeys were treated with 6\u2010aminonicotinamide at different stages of gestation. Four, treated from the twenty\u2010sixth to twenty\u2010ninth days, aborted, the other three had normal young.<\/jats:p><jats:p>Retrospective studies of therapeutic agents used at various times during pregnancy in monkeys in the colony have shown that hydroxyprogesterone caproate (Delalutin), chloramphenicol succinate (Chloromycetin), lincomycin hydrochloride (Lincocin), and benzathine penicillin G and procaine penicillin G (Longicil) have no apparent effect on the developing monkey fetus.<\/jats:p>","DOI":"10.1002\/tera.1420010205","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T23:29:16Z","timestamp":1118446156000},"page":"163-172","source":"Crossref","is-referenced-by-count":64,"title":["Teratology in the <i>Macaca mulatta<\/i>"],"prefix":"10.1002","volume":"1","author":[{"given":"K. D.","family":"Courtney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Valerio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,5]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"23","article-title":"Experimental production of malformations due to acetylsalicylate and phenylsalicylate in rats","volume":"12","author":"Baba T.","year":"1966","journal-title":"Osaka City Med. J."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401530311"},{"key":"e_1_2_1_4_1","first-page":"1","article-title":"Early abnormal embryos of the rhesus monkey","volume":"35","author":"Corner G. W.","year":"1954","journal-title":"Cont. Embryol."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)35648-5"},{"key":"e_1_2_1_6_1","first-page":"181","article-title":"Cleft lip and jaw induced in fetal rats by vincristine","volume":"48","author":"DeMeyer W.","year":"1965","journal-title":"Arch. 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Anim. Care (in press)."},{"key":"e_1_2_1_26_1","first-page":"93","article-title":"Androgen\u2010induced female pseudohermaphroditism in the monkey (Macaca mulatta): Anatomy of the reproductive organs","volume":"35","author":"Wells L. J.","year":"1954","journal-title":"Contr. 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