{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:53:15Z","timestamp":1757541195462},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,5]],"date-time":"2005-05-05T00:00:00Z","timestamp":1115251200000},"content-version":"vor","delay-in-days":13242,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1969,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A technique was developed for the intrauterine application of teratogens to study fetal rat malformations produced by benzhydrylpiperazine compounds. Millipore filters (0.2 \u00d7 0.2 cm) impregnated with 50 \u03bcg chlorcyclizine HCl, 50 \u03bcg norchlorcyclizine HCl, or HCl alone were inserted through the uterine wall and placed on either the intact amniotic sac (over the fetus) or the placenta. Filters containing norchlorcyclizine implanted on the amniotic sac on day 13 or 14 produced 30% cleft palate, while chlorcyclizine filters produced only 3% cleft palate. Limb anomalies were also seen after norchlorcyclizine\u2010 or chlorcyclizine\u2010filter insertion. The optimal time of producing these malformations was day 13 or 14 of gestation. The agents exerted localized teratogenic activity since insertion of norchlorcyclizine filters over the head area of day\u201014 fetuses resulted in 42% cleft palate, while those placed over the hindlimb produced only 11% cleft palate but 55% hindlimb malformations. Control HCl filters inserted over the fetus and norchlorcyclizine filters placed on the placenta produced no malformations.<\/jats:p>","DOI":"10.1002\/tera.1420020108","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T23:32:55Z","timestamp":1118446375000},"page":"55-65","source":"Crossref","is-referenced-by-count":15,"title":["Production of fetal rat malformations by norchlorcyclizine and chlorcyclizine after intrauterine application"],"prefix":"10.1002","volume":"2","author":[{"given":"A. L.","family":"Wilk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-114-28786"},{"key":"e_1_2_1_3_1","first-page":"241","volume-title":"Environmental Variables in Oral Disease","author":"King C. T. G.","year":"1966"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0002-9378(66)90635-1","article-title":"Teratogenic effects of buclizine and hydroxyzine in the rat and chlorcyclizine in the mouse","volume":"95","author":"King C. T. G.","year":"1966","journal-title":"Am. J. Obst. Gyn."},{"key":"e_1_2_1_5_1","first-page":"391","article-title":"Antihistamines and teratogenicity in the rat","volume":"147","author":"King C. T. G.","year":"1965","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(60)90486-2"},{"key":"e_1_2_1_7_1","first-page":"494","article-title":"Experimental alteration of the metabolism of chlorcyclizine and the incidence of cleft palate in rats","volume":"155","author":"Posner H. S.","year":"1967","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.124.3219.439"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420010111"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420020108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420020108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T09:36:49Z","timestamp":1699781809000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420020108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,2]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1969,2]]}},"alternative-id":["10.1002\/tera.1420020108"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420020108","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,2]]}}}