{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:12:36Z","timestamp":1699834356342},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,5]],"date-time":"2005-05-05T00:00:00Z","timestamp":1115251200000},"content-version":"vor","delay-in-days":13061,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1969,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Methylbis(beta\u2010chloroethyl)amine hydrochloride was applied for 1 minute to the slit vitelline membrane over different mediolateral portions of ribforming levels of 22\u2010 to 27\u2010somite chick embryos by uniformly prepared agar discs of uniform dimensions. Gross effects on rib patterns and external features (body wall, feather tracts, wings) were recorded after 10 to 11 days of incubation.<\/jats:p><jats:p>Rib patterns were essentially normal in most specimens with agar discs placed over the right lateral plate only; modifications of external features other than right wings were minimal under these circumstances. Placement of agar discs close to or over any portions of the somites and also over the lateral plate resulted in modifications both of rib patterns and external features. Related modifications occurred in vertebral and sternal components of ribs 3\u20137. Vertebral components were reduced in size, otherwise modified, or absent. Sternal components were either modified correspondingly, usually to greater degrees, or absent. Sternal components never formed in the absence of corresponding vertebral components. Similar modifications of vertebral and sternal components sometimes occurred on the left side when agar discs were applied to the right side. Modified external features (transverse grooves or depressions, body foreshortening, dorsal displacement and other modifications of breast and ventral feather tracts) appeared to be due to reduction of body musculature.<\/jats:p><jats:p>These results are compatible with the classical hypothesis that vertebral and sternal rib components and ventrolateral muscles originate exclusively from somites.<\/jats:p>","DOI":"10.1002\/tera.1420020305","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T23:35:06Z","timestamp":1118446506000},"page":"199-219","source":"Crossref","is-referenced-by-count":5,"title":["Changing body wall and rib defects after local application of nitrogen mustard to different mediolateral portions of rib\u2010forming levels of two\u2010day chick embryos"],"prefix":"10.1002","volume":"2","author":[{"given":"Robert M.","family":"Sweeney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ray L.","family":"Watterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4832-3142-6.50012-4"},{"key":"e_1_2_1_3_1","first-page":"231","article-title":"An improved \u201cegg nest\u201d for avian embryologists","volume":"41","author":"Betz T. W.","year":"1963","journal-title":"Turtox News"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401040303"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401080106"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030430409"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401080105"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401070105"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-86-21207"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401290104"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1939.0002"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401030102"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.103.2675.409"},{"key":"e_1_2_1_14_1","volume-title":"A Manual of Experimental Embryology","author":"Hamburger V.","year":"1960"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050880104"},{"key":"e_1_2_1_16_1","volume-title":"Lillie's Development of the Chick","author":"Hamilton H. L.","year":"1952"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091020407"},{"key":"e_1_2_1_18_1","first-page":"31","volume-title":"Epithelial\u2010Mesenchymal Interactions","author":"Hay E. D.","year":"1968"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0350191"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000560308"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-185X.1960.tb01326.x"},{"key":"e_1_2_1_22_1","first-page":"498","article-title":"The factors controlling the development of the dorsal root ganglia and ventral horn in Xenopus laevis (Daud.)","volume":"92","author":"Hughes A.","year":"1958","journal-title":"J. Anat."},{"key":"e_1_2_1_23_1","first-page":"60","article-title":"Comparative investigations of the action of two nitrogen mustard derivatives on the early stages of development of chick embryos","volume":"8","author":"Jurand A.","year":"1960","journal-title":"J. Embryol. Exp. Morph."},{"key":"e_1_2_1_24_1","first-page":"492","article-title":"Further investigations on the cytotoxic and morphogenetic effects of some nitrogen mustard derivatives","volume":"9","author":"Jurand A.","year":"1961","journal-title":"J. Embryol. Exp. Morph."},{"key":"e_1_2_1_25_1","first-page":"689","article-title":"Anti\u2010mesodermal activity of a nitrogen mustard derivative","volume":"11","author":"Jurand A.","year":"1963","journal-title":"J. Embryol. Exp. Morph."},{"key":"e_1_2_1_26_1","first-page":"50","article-title":"Experimental observations on the effects of the nitrogen mustards on neoplastic tissues","volume":"7","author":"Karnofsky D. A.","year":"1947","journal-title":"Canc. Res."},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.5962\/bhl.title.56223"},{"key":"e_1_2_1_28_1","first-page":"577","article-title":"Beitr\u00e4ge zur Morphologie und Entwicklungsgeschichte des Brustschulterskelettes bei den V\u00f6geln","volume":"55","author":"Knopfli W.","year":"1919","journal-title":"Jena Z. Naturw."},{"key":"e_1_2_1_29_1","first-page":"217","article-title":"A radioautographic study of the development of the somite in the chick embryo","volume":"19","author":"Langman J.","year":"1968","journal-title":"J. Embryol. Exp. Morph."},{"key":"e_1_2_1_30_1","first-page":"391","article-title":"About the forming material of the ribs and sternum. An experimental analysis in the chick embryo","volume":"11","author":"Murillo\u2010Ferrol N. L.","year":"1963","journal-title":"An. Desarrollo"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.5962\/bhl.part.75361"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001220304"},{"key":"e_1_2_1_33_1","first-page":"149","article-title":"Etude exp\u00e9rimentale de la morphogen\u00e8se de la cage thoracique chez l'embryon de Poulet: m\u00e9canismes et origine du mat\u00e9riel","volume":"21","author":"Pinot M.","year":"1969","journal-title":"J. Embryol. Exp. Morph."},{"key":"e_1_2_1_34_1","unstructured":"Powers E. L. andC.Raper1951Concentration effects of a nitrogen mustard in Paramecium. Quart. Rep. Div. Biol. Med. Res. Argonne Nat. Lab. Report ANL\u20104713 pp.94\u201395."},{"key":"e_1_2_1_35_1","first-page":"3591","article-title":"Sur la production exp\u00e9rimentale de phocom\u00e8les chez l'embryon de poulet \u00e0 l'aide d'yp\u00e9rite \u00e0 l'azote","volume":"254","author":"Salzgeber B.","year":"1962","journal-title":"C. R. Acad. Sci."},{"key":"e_1_2_1_36_1","first-page":"413","article-title":"Production \u00e9lective de la phocom\u00e9lie sous l'influence d'yp\u00e9rite azot\u00e9e","volume":"11","author":"Salzgeber B.","year":"1963","journal-title":"J. Embryol. Exp. Morph."},{"key":"e_1_2_1_37_1","first-page":"2149","article-title":"La gen\u00e8se de la phocom\u00e9lie: alt\u00e9rations observ\u00e9es dans les bourgeons de membres d'embryons de poulet trait\u00e9s par \u201cl'yp\u00e9rite azot\u00e9e.\u201d C","volume":"259","author":"Salzgeber B.","year":"1964","journal-title":"R. Acad. Sci."},{"key":"e_1_2_1_38_1","first-page":"339","article-title":"Production \u00e9lective de la phocom\u00e9lie sous l'influence d'yp\u00e9rite azot\u00e9e, chez l'embryon de poulet. II. Etude histologique des bourgeons de membres au cours du d\u00e9veloppement","volume":"16","author":"Salzgeber B.","year":"1966","journal-title":"J. Embryol. Exp. Morph."},{"key":"e_1_2_1_39_1","first-page":"395","article-title":"Sur l'\u00e9tude exp\u00e9rimentale de la gen\u00e8se de la phocom\u00e9lie chez l'embryon de poulet","volume":"264","author":"Salzgeber B.","year":"1967","journal-title":"C. R. Acad. Sci."},{"key":"e_1_2_1_40_1","first-page":"90","article-title":"\u00c9tude des malformations distales obtenues apr\u00e8s traitement \u00e0 l'yp\u00e9rite azot\u00e9e du constituant ectodermique des bourgeons de membres","volume":"267","author":"Salzgeber B.","year":"1968","journal-title":"C. R. Acad. Sci."},{"key":"e_1_2_1_41_1","first-page":"83","article-title":"\u00c9tude sur la gen\u00e8se de malformations exp\u00e9rimentales des membres chez l'embryon de poulet: microm\u00e9lie, phocom\u00e9lie, ectrom\u00e9lie. I. Traitement a l'yp\u00e9rite azot\u00e9e de bourgeons de membres entiers","volume":"1","author":"Salzgeber B.","year":"1968","journal-title":"Ann. Embryol. Morphogen."},{"key":"e_1_2_1_42_1","first-page":"756","article-title":"Do the somites contribute to the formation of the chick wing?","volume":"100","author":"Saunders J. W.","year":"1948","journal-title":"Anat. Rec."},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000141740"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000920306"},{"key":"e_1_2_1_45_1","first-page":"223","article-title":"Indirect evidence for the origin of sternal as well as vertebral ribs from the sclerotome of chick embryos","volume":"5","author":"Sweeney R.","year":"1965","journal-title":"Am. Zool."},{"key":"e_1_2_1_46_1","doi-asserted-by":"crossref","unstructured":"Sweeney R. andR. L.Watterson1969Rib development in chick embryos analyzed by means of tantalum foil blocks.Am. J. Anat. in press.","DOI":"10.1002\/aja.1001260202"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(67)90018-8"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.5962\/bhl.part.75388"},{"key":"e_1_2_1_49_1","first-page":"446","article-title":"Modified ribs produced by application of nitrogen mustard to the thoracic level of neural tubes of two\u2010day chick embryos","volume":"124","author":"Watterson R. L.","year":"1956","journal-title":"Anat. Rec."},{"key":"e_1_2_1_50_1","first-page":"447","article-title":"Sequence of changes in neural tubes of chick embryos exposed locally to nitrogen mustard at two days of incubation","volume":"124","author":"Watterson R. L.","year":"1956","journal-title":"Anat. Rec."}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420020305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420020305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T09:25:53Z","timestamp":1699781153000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420020305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,8]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1969,8]]}},"alternative-id":["10.1002\/tera.1420020305"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420020305","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,8]]}}}