{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T14:40:27Z","timestamp":1699800027566},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,9]],"date-time":"2005-05-09T00:00:00Z","timestamp":1115596800000},"content-version":"vor","delay-in-days":12151,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1972,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Radioactive 5\u2010fluoro\u20102\u2032\u2010deoxyuridine (FUdR) was administered to mice on day 12 of pregnancy, and the resulting radioactivity was measured in embryos, placentas, and maternal liver and spleen. The FUdR was taken up rapidly by the maternal tissues and embryos and was incorporated into nucleic acids within 1 hour of administration. In the maternal tissues the quantity of FUdR incorporated into nucleic acids within 1 hour of administration was greatly increased by increasing the applied dose. In embryos, however, only a slight increase was observed. After 0.14 mg\/kg FUdR the quantity incorporated into nucleic acids reached its peak within 1 hour, and increased no further. After a dose ten times larger the quantity of FUdR incorporated into nucleic acids increased steadily in all tissues tested until nearly 8 hours after application. A greater amount of FUdR was incorporated into maternal spleen than into embryos.<\/jats:p>","DOI":"10.1002\/tera.1420050111","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T22:24:15Z","timestamp":1118442255000},"page":"71-80","source":"Crossref","is-referenced-by-count":10,"title":["Teratogenic effects of 5\u2010fluoro\u20102\u2032\u2010deoxyuridine in pregnant mice"],"prefix":"10.1002","volume":"5","author":[{"given":"Kazuo","family":"Ohmori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"554","article-title":"The teratogenic effects of 5\u2010fluorocytosine in the rat","volume":"29","author":"Chaube S.","year":"1969","journal-title":"Canc. 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A.","year":"1958","journal-title":"Proc. Am. Ass. Canc. Res."},{"key":"e_1_2_1_10_1","first-page":"307","article-title":"Teratogenic effects in rats of growth inhibiting chemicals, including studies on thalidomide","volume":"18","author":"Murphy M. L.","year":"1962","journal-title":"Clin. Proc. Child. Hosp. Wash., D. C."},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0021-9258(17)41524-9","article-title":"A method for the determination of desoxyribo\u2010nucleic acid, ribonucleic acid, and phospho\u2010proteins in animal tissues","volume":"161","author":"Schmidt G.","year":"1945","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_12_1","first-page":"2129","article-title":"Clinical evaluation of 5\u2010bromo\u20105\u2010fluoro\u20106\u2010me\u2010thoxy\u2010dihydro\u20102\u2032\u2010deoxyuridine","volume":"27","author":"Van Dyk J. J.","year":"1967","journal-title":"Canc. 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