{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T14:10:30Z","timestamp":1699798230262},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,9]],"date-time":"2005-05-09T00:00:00Z","timestamp":1115596800000},"content-version":"vor","delay-in-days":12030,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1972,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The distribution and metabolism of labeled triamcinolone acetonide was compared in A\/J, C3H, and CBA inbred mice. <jats:sup>3<\/jats:sup>H\u2010Triamcinolone acetonide (5 mg\/kg) administered at day 11.5 of gestation caused 100% cleft palate in A\/J, 40% in C3H, and 0% in CBA. A half to 3 h later CBA maternal tissue (skeletal muscle) contained 60% as much radioactivity as did A\/J and C3H tissue. CBA mice metabolized the drug faster than A\/Js and C3Hs, although levels of unmetabolized drug and metabolites in livers of the three strains were not significantly different. As a consequence of the increased maternal metabolism of the drug in CBAs the level of unmetabolized drug in CBA embryos was 60% of that in A\/J and C3H embryos. It is concluded that the cleft palate resistance of CBA embryos derives from the increased maternal metabolism of administered teratogen. However, the greater resistance of C3H than A\/J is probably not due to increased metabolism, nor to altered distribution of drug.<\/jats:p>","DOI":"10.1002\/tera.1420050308","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T22:30:01Z","timestamp":1118442601000},"page":"335-343","source":"Crossref","is-referenced-by-count":30,"title":["Distribution and metabolism of triamcinolone acetonide in inbred mice with different cleft palate sensitivities"],"prefix":"10.1002","volume":"5","author":[{"given":"Ernest F.","family":"Zimmerman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Bowen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420040106"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/S0021-9258(18)64239-5","article-title":"Metabolic fate of a synthetic corticosterold (tri\u2010amcinolone) in the dog","volume":"236","author":"Florini J. R.","year":"1961","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_4_1","first-page":"100","article-title":"Developmental thresholds and teratogenetics","volume":"30","author":"Fraser F. C.","year":"1971","journal-title":"Fed. Proc."},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1542\/peds.8.4.527","article-title":"Production of congenital defects in the offspring of pregnant mice treated with cortisone","volume":"8","author":"Fraser F. C.","year":"1951","journal-title":"Pediatrics"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030430411"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/genetics\/39.2.185","article-title":"The inheritance of susceptibility to the teratogenic action of cortisone in mice","volume":"39","author":"Kalter H.","year":"1954","journal-title":"Genetics"},{"key":"e_1_2_1_8_1","first-page":"895","article-title":"The susceptibility to cortisone induced cleft palate of hybrids between resistant and susceptible strains of inbred mice","volume":"48","author":"Kalter H.","year":"1963","journal-title":"Genetics"},{"key":"e_1_2_1_9_1","first-page":"57","volume-title":"Teratology: Principles and Techniques","author":"Kalter H.","year":"1965"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(70)90005-6"},{"key":"e_1_2_1_11_1","first-page":"369","article-title":"Studies on the closure of the secondary palate. IV. Autoradiographic and histochemical studies of mouse embryos from cortisone\u2010treated mothers","volume":"4","author":"Larsson K. S.","year":"1962","journal-title":"Acta Morph. Neerl. Scand."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-129-33256"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091450202"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091500309"},{"key":"e_1_2_1_15_1","first-page":"71","article-title":"Tritiated cortisone distribution and induced cleft palate in mice","volume":"4","author":"Nasjleti C. E.","year":"1967","journal-title":"J. Oral Ther. Pharmacol."},{"key":"e_1_2_1_16_1","first-page":"2433","volume-title":"Handbook of Physiology","author":"Schanker L. S.","year":"1968"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.149.3686.862"},{"key":"e_1_2_1_18_1","first-page":"176","article-title":"Closure of the secondary palate in three strains of mice","volume":"4","author":"Walker B. E.","year":"1956","journal-title":"J. Embryol. Exp. Morph."},{"key":"e_1_2_1_19_1","first-page":"201","article-title":"The embryology of cortisone\u2010induced cleft palate","volume":"5","author":"Walker B. E.","year":"1956","journal-title":"J. Embryol. Exp. Morph."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.67.2.779"},{"key":"e_1_2_1_21_1","first-page":"211","article-title":"Cleftpalate sensitivity to triamcinolone in inbred mice","volume":"3","author":"Zimmerman E. F.","year":"1970","journal-title":"Teratology"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420050110"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420050308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420050308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T13:56:01Z","timestamp":1699797361000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420050308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,6]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1972,6]]}},"alternative-id":["10.1002\/tera.1420050308"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420050308","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,6]]}}}