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Cerebral cortical tissues plus neuroretinal tissues with associated mesenchyme from 4 \u00bd\u2010day embryos were studied on millipore tilters throughout a culture period of 120 h. Brief exposure (5\u201315 min) to divalent ion\u2010depleted media variably disturbed the organization of the neuroepithelial explants. The histological responses following subsequent culture in a complete medium included simulations of a number of CNS malformations (neuroretinal folds, rosette formations, ectopic cellular aggregations, and cellular depletions) previously produced by various teratogens. The adaptation of this procedure to the study of the response potential of the early embryonic tissues enabled delineation of the processes (the degree of interference on the adhesive mechanisms) presumably operative in the development of these malformations.<\/jats:p>","DOI":"10.1002\/tera.1420060214","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T22:33:23Z","timestamp":1118442803000},"page":"215-225","source":"Crossref","is-referenced-by-count":3,"title":["A direct analysis of early chick embryonic neuroepithelial responses following exposure to EDTA"],"prefix":"10.1002","volume":"6","author":[{"given":"Eugene","family":"Daniels","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith L.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(69)90205-5"},{"key":"e_1_2_1_3_1","first-page":"131","article-title":"The teratogenic effects of azo dyes","volume":"1","author":"Beck F.","year":"1966","journal-title":"Adv. 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