{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:57:24Z","timestamp":1777543044127,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,9]],"date-time":"2005-05-09T00:00:00Z","timestamp":1115596800000},"content-version":"vor","delay-in-days":11847,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1972,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Incidence rates, specific for maternal age and birth order, were calculated for 16 categories of congenital malformations reported on birth certificates from a population of more than 8 million registered white, single livebirths. With maternal age held constant none of the malformations showed increasing incidence as birth order increased. Hypospadias, esophageal defects, omphalocele, and Down syndrome showed evidence of decreasing incidence as birth order increased. Some of the other malformation categories showed an excess of first births in most age groups, while no relation to birth order was observed in the incidence of other malformations. By contrast, most of the malformations analyzed exhibited increasing incidence as maternal age increased. Especially high rates of several malformations were observed among first births to women over 40 years of age.<\/jats:p>","DOI":"10.1002\/tera.1420060304","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T22:34:09Z","timestamp":1118442849000},"page":"271-279","source":"Crossref","is-referenced-by-count":76,"title":["Independent effects of maternal age and birth order on the incidence of selected congenital malformations"],"prefix":"10.1002","volume":"6","author":[{"given":"Sylvia","family":"Hay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Barbano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.40.213.548"},{"key":"e_1_2_1_3_1","first-page":"98","article-title":"An examination of familial data for associated birth\u2010order effects in the presence of malformations of the central nervous system","volume":"18","author":"Bennett B. M.","year":"1964","journal-title":"Br. J. Prev. Soc. Med."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.2307\/4593040"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5467.895"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(61)90055-1"},{"key":"e_1_2_1_7_1","first-page":"115","article-title":"Congenital malformations of the central nervous system in Scotland","volume":"12","author":"Edwards J. H.","year":"1958","journal-title":"Br. J. Prev. Soc. Med."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.36.188.420"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-88-2-527"},{"key":"e_1_2_1_10_1","first-page":"141","article-title":"Utilization of birth certificates in epidemiologic studies of cleft lip and palate","volume":"2","author":"Greene J. C.","year":"1965","journal-title":"Cleft Pal. J."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.2307\/4593178"},{"key":"e_1_2_1_12_1","first-page":"205","article-title":"Incidence of clefts and parental age","volume":"4","author":"Hay S.","year":"1967","journal-title":"Cleft Pal. J."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420040303"},{"key":"e_1_2_1_14_1","volume-title":"A Classification of Congenital Malformations","author":"Hay S.","year":"1968"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM194906232402501"},{"key":"e_1_2_1_16_1","first-page":"15","volume-title":"Hermaphroditism, Genital Anomalies and Related Endocrine Disorders","author":"Jost A.","year":"1958"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.2307\/4594425"},{"key":"e_1_2_1_18_1","first-page":"178","article-title":"Association of congenital malformation of the heart with birth rank and maternal age","volume":"6","author":"MacMahon B.","year":"1952","journal-title":"Br. J. Soc. Med."},{"key":"e_1_2_1_19_1","first-page":"176","article-title":"The incidence of harelip and cleft palate related to birth rank and maternal age","volume":"5","author":"MacMahon B.","year":"1953","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_2_1_20_1","first-page":"168","article-title":"An investigation of 69 cases of exomphalos","volume":"5","author":"McKeown T.","year":"1953","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_2_1_21_1","first-page":"9","article-title":"Drug\u2010induced intersexuality in mammals","volume":"7","author":"Neumann F.","year":"1969","journal-title":"J. Reprod. Fert., Suppl."},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-196446030-00008"},{"key":"e_1_2_1_23_1","first-page":"183","article-title":"Congenital malformations of the central nervous system. I. A survey of 930 cases","volume":"3","author":"Record R. G.","year":"1949","journal-title":"Br. J. Soc. Med."},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1136\/hrt.15.4.376","article-title":"Observations relating to the aetiology of patent ductus arteriosus","volume":"15","author":"Record R. G.","year":"1953","journal-title":"Br. Heart J."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1969.tb01492.x"},{"key":"e_1_2_1_26_1","first-page":"51","article-title":"Maternal age and birth rank in the aetiology of mon\u2010golism","volume":"9","author":"Smith A.","year":"1955","journal-title":"Br. J. Prev. Soc. Med."},{"key":"e_1_2_1_27_1","first-page":"687","article-title":"Effects of maternal age and birth order on the risk of mongolism and leukemia","volume":"37","author":"Stark C. R.","year":"1966","journal-title":"J. Nat. Cancer Inst."},{"key":"e_1_2_1_28_1","volume-title":"Congenital Malformations Surveillance Report (June)","author":"U. S. Department of Health, Education, and Welfare","year":"1971"},{"key":"e_1_2_1_29_1","first-page":"24","article-title":"A study of seasonal incidence of congenital malformations in the United States","volume":"24","author":"Wehrung D.","year":"1970","journal-title":"Br. J. Prev. Soc. Med."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-196307000-00008"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1302\/0301-620X.46B3.445","article-title":"Family studies and the cause of congenital club foot","volume":"46","author":"Wynne\u2010Davies R.","year":"1964","journal-title":"J. Bone J. Surg."}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420060304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420060304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T04:32:23Z","timestamp":1699763543000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420060304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,12]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1972,12]]}},"alternative-id":["10.1002\/tera.1420060304"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420060304","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,12]]}}}