{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T09:16:48Z","timestamp":1699780608622},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,10]],"date-time":"2005-05-10T00:00:00Z","timestamp":1115683200000},"content-version":"vor","delay-in-days":11483,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1973,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anencephaly and spina bifida, for some purposes, can be regarded as a single entity (ASB). The seasonal peak incidence has pointed to an influence of potato quality, that quality being worst in May or June. The ASB incidence is highest among infants conceived in late April, the damage occurring predominantly in May or June. In addition to this seasonal relation, I have found two other relations with potato quality. These are a concordance geographically between potato\u2010blight severity and ASB incidence; and a year\u2010to\u2010year concordance between these two variables. Perhaps some metabolite of the infected potato (say a phytoalexin), or a metabolite of one of its pathogens, accumulates during winter storage and is maximal in May or June at the likely time of teratogenesis. The year\u2010to\u2010year correlation has been confirmed in previously published data. The claim of 95% preventability in the British Isles by complete potato avoidance, a claim based on these associations, has not yet been tested. However, recent anecdotal data has confirmed that preventability cannot quite reach 100% by this means alone, even in the British Isles. I believe that women of childbearing age in whom conception is a possibility should avoid imperfect potatoes.<\/jats:p>","DOI":"10.1002\/tera.1420080314","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T22:38:22Z","timestamp":1118443102000},"page":"321-323","source":"Crossref","is-referenced-by-count":12,"title":["Prevention of anencephaly and spina bifida in man"],"prefix":"10.1002","volume":"8","author":[{"given":"J. H.","family":"Renwick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,10]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"173","volume-title":"Applied Regression Analysis","author":"Draper N.","year":"1966"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)92152-1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-84-5-1206"},{"key":"e_1_2_1_5_1","first-page":"219","article-title":"Anencephalus and dietary intakes","volume":"26","author":"Knox E. G.","year":"1972","journal-title":"Br. J. Prev. Soc. 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