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Studies using maternal injections of <jats:sup>109<\/jats:sup>Cd at 10 days' gestation indicated that Cd crossed the placenta in both the sensitive and resistant strains since <jats:sup>109<\/jats:sup>Cd was detected in embryos and placentas at 1\u201324 h postinjection. Fractionation of the tissue cytosol preparations by Sephadex gel G\u2010200 filtration indicated that free Cd was absent from embryos and placentas of both strains. In embryonic cytosol of both strains <jats:sup>109<\/jats:sup>Cd was associated with fractions showing elution characteristics indicative of Cd\u2010binding protein (metallothionein, MW 10,000). In placental cytosol of both strains <jats:sup>109<\/jats:sup>Cd was predominantly associated with fractions whose characteristics indicated a moiety of approximately 19,000 MW. The two strains differed only in the amount of Cd present in the embryonic cytosol \u2014 B10 embryos had more Cd in the binding\u2010protein fractions than did NAW embryos. To evaluate the placental capacity for transfering Cd throughout gestation females were injected on day 13 and 17 of gestation; <jats:sup>l09<\/jats:sup>Cd was detected in embryos, fetuses, and placentas of both strains 4 and 24 h postinjection, In contrast with day\u201010 results gel profiles from offspring and placentas were qualitatively similar, i.e., the heavier (dimeric?) Cd\u2010binding molecule was not present in placental cytosol. B10 embryonic mortality was greater at these later gestational times.<\/jats:p>","DOI":"10.1002\/tera.1420100307","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T22:42:50Z","timestamp":1118443370000},"page":"243-261","source":"Crossref","is-referenced-by-count":54,"title":["Differential cadmium\u2010induced embryotoxicity in two inbred mouse strains 1. 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