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The incidence and degree of expression of the effects (polydactyly, ectrodactyly, radial hemimelia, tibial hemimelia, pelvic girdle shifts, deformed caudal vertebrae) varied according to the teratogen and dose level. The addition of an equimolecular amount of thymidine, thymine, or uracil greatly potentiated the effects of 20 mg\/kg 5\u2010FU, usually resulting in death of the embryos. The addition of an equimolecular amount of thymidine but not of thymine or uracil partly protected against the effects of 5\u2010FUdR. Both teratogens increased the expression of 1 st on the limb skeleton. The interactions of the teratogens with the major gene were inhibited by minus\u2010 and promoted by plus\u2010modifying genes of 1st. The effects of the teratogenic treatments may be mediated by cell death.<\/jats:p>","DOI":"10.1002\/tera.1420110102","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T22:48:53Z","timestamp":1118443733000},"page":"1-19","source":"Crossref","is-referenced-by-count":14,"title":["The effects of 5\u2010fluorouracil and 5\u2010fluorodeoxyuridine used alone and in combination with normal nucleic acid precursors on development of mice in lines selected for low and high expression of strong's luxoid gene"],"prefix":"10.1002","volume":"11","author":[{"given":"Paulinus F.","family":"Forsthoefel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Louise","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"181","article-title":"The teratogenic effects of the recent drugs active in cancer chemotherapy","volume":"3","author":"Chaube S.","year":"1969","journal-title":"Adv. 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