{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:19:58Z","timestamp":1791141598857,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T00:00:00Z","timestamp":1115856000000},"content-version":"vor","delay-in-days":10877,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1975,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epidemiologic studies, retrospective and prospective, were done on 1500 abortions collected from 1966\u20101972. No secular or seasonal variations were observed. From the analysis of the relative frequencies of the different types of chromosome anomalies it is estimated that 1 out of every 2 conceptions has a chromosome anomaly. Maternal\u2010age influence was found only for the autosomal trisomy group, mainly D and G trisomies. No effect of oral contraceptives was discovered. An increased frequency of chromosome anomalies occurred after ovulation\u2010inducing therapy and after occupational exposure of the father to irradiation. No variations in the fertility rate and in the frequency of congenital malformations in births following abortions was noted. The incidence of recurring abortion was mainly influenced by the reproductive history of the couple before the karyotyped abortion.<\/jats:p>","DOI":"10.1002\/tera.1420120103","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T22:49:46Z","timestamp":1118443786000},"page":"11-26","source":"Crossref","is-referenced-by-count":527,"title":["Retrospective and prospective epidemiological studies of 1500 karyotyped spontaneous human abortions"],"prefix":"10.1002","volume":"12","author":[{"given":"Jo\u00eblle","family":"Bou\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Bou\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,12]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"305","volume-title":"Chromosomal Errors in Relation to Reproductive Failure","author":"Alberman E.","year":"1973"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1972.tb00768.x"},{"key":"e_1_2_1_4_1","first-page":"264","article-title":"Effect of gestaiional and maternal age in early abortion","volume":"35","author":"Arakaki D. T.","year":"1970","journal-title":"Obst. Gyn."},{"key":"e_1_2_1_5_1","first-page":"141","article-title":"Etudes chromosomiques et anatomiques des grossesses suivant l'arr\u00e8t des contraceptifs","volume":"2","author":"Bou\u00e9 A.","year":"1973","journal-title":"J. Gyn. Obst. Biol. Reprod."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-2892-6_22"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)92261-7"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00278402"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","unstructured":"Bou\u00e9 A. J. G.Bou\u00e9 S.Cure C.DeluchatandN.Perraudin1975In vitro cultivation of cells from aneuploid human embryos initiation of cell lines and longevity of the cultures. In Vitro in press.","DOI":"10.1007\/BF02616379"},{"key":"e_1_2_1_10_1","first-page":"179","article-title":"Les aberrations chromosomiques dans les avortements","volume":"10","author":"Bou\u00e9 J. G.","year":"1967","journal-title":"Ann. Genet."},{"key":"e_1_2_1_11_1","first-page":"330","volume-title":"Biology and Pathology of Aging Gametes","author":"Bou\u00e9 J. G.","year":"1974"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/0002-9378(73)91013-2","article-title":"Outcome of pregnancies following a spontaneous abortion with chromosomal anomalies","volume":"116","author":"Bou\u00e9 J. G.","year":"1973","journal-title":"Am. J. Obst. Gyn."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(67)90488-7"},{"key":"e_1_2_1_14_1","first-page":"343","article-title":"Chromosome studies in selected spontaneous abortions. 1. Conception after oral contraceptives","volume":"103","author":"Carr D. H.","year":"1970","journal-title":"Can. Med. Ass. J."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470715277.ch3"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1963.tb01325.x"},{"key":"e_1_2_1_17_1","first-page":"255","volume-title":"Chromosomal Errors in Relation to Reproductive Failure","author":"Gropp A.","year":"1974"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000301716"},{"key":"e_1_2_1_19_1","first-page":"223","article-title":"Note towards an epidemiology of spontaneous abortion","volume":"15","author":"James W. H.","year":"1963","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_2_1_20_1","first-page":"539","article-title":"Banding analysis of chromosomal karyotypes in spontaneous abortion","volume":"25","author":"Kajii T.","year":"1973","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_2_1_21_1","first-page":"371","volume-title":"Chromosomal Errors in Relation to Reproductive Failure","author":"Klinger H. P.","year":"1973"},{"key":"e_1_2_1_22_1","volume-title":"Epidemiology of Mongolism","author":"Lilienfeld A. M.","year":"1969"},{"key":"e_1_2_1_23_1","first-page":"219","volume-title":"Chromosomal Errors in Relation to Reproductive Failure","author":"Pearson P. L.","year":"1974"},{"key":"e_1_2_1_24_1","volume-title":"Down's Anomaly","author":"Penrose L. S.","year":"1966"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1966.tb06077.x"},{"key":"e_1_2_1_26_1","first-page":"867","article-title":"Smoking and pregnancy. Results of a prospective study of 6989 women","volume":"17","author":"Schwartz D.","year":"1972","journal-title":"Rev. Eur. Etud."},{"key":"e_1_2_1_27_1","first-page":"683","article-title":"Cytogenetics of spontaneously aborted human fetuses","volume":"30","author":"Stenchever M. A.","year":"1967","journal-title":"Obst. Gyn."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196504222721601"},{"key":"e_1_2_1_29_1","first-page":"81","volume-title":"Chromosomal Errors in Relation to Reproductive Failure","author":"Therkelsen A. J.","year":"1974"},{"key":"e_1_2_1_30_1","first-page":"1","article-title":"Spontaneous abortion risks in man: data from reproduction histories collected in a medical genetic unit","volume":"16","author":"Warburton D.","year":"1964","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_2_1_31_1","series-title":"Excerpta Med. Int. Cong. Ser. No. 204","first-page":"157","volume-title":"Congenital Malformations","author":"Witschi E.","year":"1970"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420120103","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420120103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T07:41:30Z","timestamp":1699774890000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420120103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,8]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1975,8]]}},"alternative-id":["10.1002\/tera.1420120103"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420120103","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,8]]}}}