{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T08:10:47Z","timestamp":1699776647650},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,16]],"date-time":"2005-05-16T00:00:00Z","timestamp":1116201600000},"content-version":"vor","delay-in-days":10759,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1975,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A technique was developed for injecting agents into the yolk sac of rabbits to study their teratogenic effects, On the 9th day of gestation the rabbits were laparotomized during ether\u2010oxygen narcosis, The test substance was injected into the yolk sacs in one horn of the uterus, and as control the corresponding solvent was iryected into the other horn. On the 28th day of gestation the rabbits were killed, resorptions coumcd, and fetuses examined for maliormations. Three series of studies were made; physioiogical saline; polyvinylpyrrolidone; and doxycycline dissolved in Polyvinylpyrrolidone (DIP). The rate of resorptions and malformations significantly increased after injection of Vibravenos, As polyvinylpyrrolidone was not teratogenic it is concluded that the teratogenic effects of DIP were probablily caused by doxycycline.<\/jats:p>","DOI":"10.1002\/tera.1420120312","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T22:51:43Z","timestamp":1118443903000},"page":"297-301","source":"Crossref","is-referenced-by-count":6,"title":["The teratogenic effects in rabbits of doxycycline, dissolved in polyvinylpyrrolidone, injected into the yolk sac"],"prefix":"10.1002","volume":"12","author":[{"given":"Uwe","family":"Claussen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Willi","family":"Breuer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,16]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000239846"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(60)90061-3"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(60)90011-7"},{"key":"e_1_2_1_5_1","first-page":"610","article-title":"Relationship of teratogenic effect and transplacental passage of a drug (French)","volume":"164","author":"Cahen R.","year":"1970","journal-title":"C. 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