{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T14:52:50Z","timestamp":1699800770236},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,13]],"date-time":"2005-05-13T00:00:00Z","timestamp":1115942400000},"content-version":"vor","delay-in-days":10512,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1976,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The teratogenicity of \u03b2\u2010aminopropionitrile (\u03b2APN) was evaluated in golden Syrian hamsters; single doses of 1250, 2500, and 3750 mg\/kg given on days 7\u201213 produced fetal mortality, growth retardation and malformations. All time\u2010dose combinations produced gross external abnormalities with the highest rate (92.5%) occurring following day\u201012 treatment. High frequencies of skeletal abnormalities including deformities of the ribs, fibula, and scapula occurred after days\u201010\u201212 treatment. Deformed ribs occurred in 100% of fetuses exposed on day ll to any of the dosages. The types of abnormality generally resembled those produced by lathyrogens in other species except for exencephaly and encephalocele, which occurred after treatment on day 7. These results indicate that \u03b2APN is a typical teratogen, capable of producing abnormalities of the central nervous system early in gestation, and may reflect a broader mechanism for its activity than previously suggested.<\/jats:p>","DOI":"10.1002\/tera.1420140107","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:10:45Z","timestamp":1118499045000},"page":"43-52","source":"Crossref","is-referenced-by-count":24,"title":["The teratogenic effects of \u03b2\u2010aminopropionitrile in hamsters"],"prefix":"10.1002","volume":"14","author":[{"given":"M. J.","family":"Wiley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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