{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T11:32:55Z","timestamp":1699788775125},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,17]],"date-time":"2005-05-17T00:00:00Z","timestamp":1116288000000},"content-version":"vor","delay-in-days":10332,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1977,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of urethan on ICR\/JCL mouse limbs were examined in forelimbs of day\u201011 embryos cultured in concentrations of 0, 50, and 100 \u03bcg\/ml for one to four days, and in forelimbs of day\u201012 embryos and in fore\u2010 and hind limbs of day\u201013 embryos in 0, 10, 50, and 100 \u03bcg\/ml for one to four days. Urethan did not cause digital malformations in day\u201011 limbs but induced syndactyly in day\u201012 forelimbs and polydactyly in day\u201012 forelimbs and day\u201013 fore\u2010 and hind limbs. The polydactyly may have been due to effects on mesenchymal cells producing localized cell proliferation, whereas syndactyly may have been due to effects on precartilage cells, resulting in excess migration of mesenchymal cells toward the digits, leaving the connective tissue at the interdigital space to develop inadequately.<\/jats:p>","DOI":"10.1002\/tera.1420150112","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:13:44Z","timestamp":1118499224000},"page":"89-96","source":"Crossref","is-referenced-by-count":4,"title":["Digital anomalies of mouse limbs induced by treatment with urethan in vitro"],"prefix":"10.1002","volume":"15","author":[{"given":"Yoshiko","family":"Yasuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(72)90137-6"},{"key":"e_1_2_1_3_1","first-page":"249","article-title":"The effects of 6\u2010diazo\u20105\u2010oxo\u2010L\u2010norleucine (DON) on the development of mouse limb buds in vitro","volume":"5","author":"Aydelotte M. 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Nippon."},{"key":"e_1_2_1_19_1","first-page":"19","article-title":"Effects of the change in environmental temperature on the incidence of malformations in the mouse fetuses induced by ethylurethane injection","volume":"11","author":"Tanioka Y.","year":"1971","journal-title":"Congen. Anom."},{"key":"e_1_2_1_20_1","first-page":"259","article-title":"The effect of thio\u2010TEPA on the fore limbbuds of mouse embryos observed in vitro","volume":"41","author":"Yamamura H.","year":"1966","journal-title":"Acta Anat. 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