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Exencephaly was associated with amniotic fluid alpha\u2010fetoprotein concentrations which were significantly elevated over those of Vitamin A\u2010treated non\u2010exencephalic and of untreated fetuses. Amniotic fluid albumin concentrations also were higher in the exencephalic fetuses than in the non\u2010exencephalic fetuses. Serum alpha\u2010fetoprotein and albumin concentrations were lower in the exencephalic than in the non\u2010exencephalic fetuses. The results are consistent with simple diffusion across a defective barrier as the cause of elevated amniotic fluid alpha\u2010fetoprotein concentrations in the presence of open neural tube defects. This experimental model of neural tube defects results in changes in amniotic fluid alpha\u2010fetoprotein similar to those changes found in human amniotic fluid alpha\u2010fetoprotein concentrations in the presence of neural tube defects.<\/jats:p>","DOI":"10.1002\/tera.1420160112","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T13:09:26Z","timestamp":1118495366000},"page":"71-78","source":"Crossref","is-referenced-by-count":2,"title":["Alpha\u2010fetoprotein and albumin in experimentally\u2010induced exencephaly in the rat"],"prefix":"10.1002","volume":"16","author":[{"given":"Carol J.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip C.","family":"Kelleher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(74)90413-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1975.tb01505.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)92597-6"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/oxfordjournals.bmb.a071317","article-title":"Prenatal diagnosis \u2013 chemical methods","volume":"32","author":"Brock D. 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