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Palate closure (100%) in PBS control animals occurred by 14<jats:sup>10<\/jats:sup>.<\/jats:p><jats:p>One day post MeHg administration, total fetal protein was decreased 22% while DNA content was unaltered. Protein was maximally decreased (28%) on 14<jats:sup>6<\/jats:sup> and, thereafter, returned toward control levels. Alterations in DNA content followed a similar pattern; but the maximal decrease (32%) occurred on 15<jats:sup>6<\/jats:sup>.<\/jats:p><jats:p>The rate of fetal protein synthesis was depressed 5% at 12<jats:sup>9<\/jats:sup> and between 20% to 26% from this time to 13<jats:sup>6<\/jats:sup> (end of observation). The agreement between the calculated decrease in protein synthesis (19%) and the measured decrease in protein content (22%) suggests that a reduction in protein synthesis is responsible for the decreased fetal protein content.<\/jats:p><jats:p>Pacental blood flow and fetal water space, measured with <jats:sup>3<\/jats:sup>H \u2013 H<jats:sub>2<\/jats:sub>O at 12<jats:sup>18<\/jats:sup>, were not affected by MeHg treatment. However, fetal free amino acid concentrations at 12<jats:sup>18<\/jats:sup> were generally decreased (alanine, 23.0%; valine, 9.7%; methionine, 22. 6%; isoleucine, 12.0%; leucine, 18.2%) while uptake of the non\u2010metabolizable amino acid, <jats:sup>14<\/jats:sup>C\u2010cycloleucine, was decreased 23%. From this, it is concluded that the growth inhibitory effects of MeHg are related, at least in part, to impaired placental\/fetal transfer of amino acids.<\/jats:p>","DOI":"10.1002\/tera.1420160213","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:11:41Z","timestamp":1118535101000},"page":"187-194","source":"Crossref","is-referenced-by-count":37,"title":["Effects of methyl mercury on murine fetal amino acid uptake, protein synthesis and palate closure"],"prefix":"10.1002","volume":"16","author":[{"given":"Fred C.","family":"Olson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J.","family":"Massaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,31]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0021-9258(18)81371-0","article-title":"Transfer of amino acids across the intestine: A new model amino acid","volume":"237","author":"Akedo H.","year":"1962","journal-title":"J. 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