{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T21:25:27Z","timestamp":1785792327967,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,17]],"date-time":"2005-05-17T00:00:00Z","timestamp":1116288000000},"content-version":"vor","delay-in-days":9908,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1978,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The antitumor drugs adriamycin and daunomycin were evaluated for effects on embryonal and fetal development in the rat and rabbit. Doses of adriamycin ranging from 1\u20102 mg\/kg\/day or daunomycin ranging from 1\u20104 mg\/kg\/day were administered ip to pregnant rats on days 6\u201015, 6\u20109, 9\u201012 or 12\u201015 of gestation. Both drugs were teratogenic in the rat, particularly when administered on days 6\u201015 or 6\u20109 of gestation. Relatively few anomalies resulted from treatment on days 9\u201012 or 12\u201015. On a mg\/kg basis, adriamycin was the more potent teratogen, producing major anomalies at doses as low as 1.25 mg\/kg. Similar anomalies, but at a lower incidence, were produced by daunomycin at dose levels of 4 mg\/kg. Characteristic malformations included esophageal and intestinal atresia, tracheo\u2010esophageal fistula, hypoplasia of the urinary bladder and various cardiovascular anomalies. Neither drug was teratogenic when given iv to rabbits at doses up to and including 0.6 mg\/kg\/day on days 6\u201018 of gestation, but a high incidence of abortion occurred in rabbits treated with adriamycin.<\/jats:p>","DOI":"10.1002\/tera.1420170207","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:26:43Z","timestamp":1118500003000},"page":"151-157","source":"Crossref","is-referenced-by-count":98,"title":["Teratogenicity of adriamycin and daunomycin in the rat and rabbit,"],"prefix":"10.1002","volume":"17","author":[{"given":"Daniel J.","family":"Thompson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Molello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Strebing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene L.","family":"Dyke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"2565","article-title":"Acute leukemia treatment","volume":"27","author":"Bernard J.","year":"1967","journal-title":"Cancer Res."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(67)90372-8"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520292609115636"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(66)90136-0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1959.73000340001013"},{"key":"e_1_2_1_7_1","first-page":"150","volume-title":"The Surgery of Infancy and Childhood","author":"Gross R. 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