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Gestation day 11 is the most sensitive time. The teratologies obtained after various schedules of treatment include malformations of the snout (100%), septal heart defects (100%), diaphragmatic hernias (100%), cryptorchism (100%), cervical pockets (100%) and absent or small irregular thymus (92%). Some of these data, namely of the heart, face and thymus, cluster in patterns that indicate that the action of the drug is upon a time\u2010restricted developmental process. These periods of sensitivity are subsiding or have ended before primordia of these structures appear, but they coincide with the proliferation and migration of those mesenchyme cells that will eventually form or contribute to the structures affected. It is postulated that the drug acts on these mesenchyme cells, or on the extracellular matrix that provides the necessary framework for their dispersal.<\/jats:p>","DOI":"10.1002\/tera.1420180104","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:27:09Z","timestamp":1118500029000},"page":"5-15","source":"Crossref","is-referenced-by-count":57,"title":["Teratogenic action of a bis(dichloroacetyl)diamine on rats: Patterns of malformations produced in high incidence at time\u2010limited periods of development"],"prefix":"10.1002","volume":"18","author":[{"given":"Plato","family":"Taleporos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miklos P.","family":"Salgo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Oster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900390103"},{"key":"e_1_2_1_3_1","first-page":"539","volume-title":"Organogenesis","author":"Auerbach R.","year":"1965"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1071\/BI9540179","article-title":"Time relations and their significance in the ovulation and penetration of eggs in rats and rabbits","volume":"7","author":"Austin C. 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