{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:54:45Z","timestamp":1790146485076,"version":"4.0.1"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,17]],"date-time":"2005-05-17T00:00:00Z","timestamp":1116288000000},"content-version":"vor","delay-in-days":9725,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1978,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The teratogenic effects of trypan blue given to pregnant rats and ferrets at equivalent stages of embryonic development are described. In the rat the well known teratogenicity of the dye at 8.5 days of gestation and the surprising cessation of teratogenic effect at 11.5 days (20+ somites) is confirmed. In the ferret the drug is teratogenic both at 13 and 18 days of gestation though the principal abnormalities seen are different to those described in the rat. It has been suggested that the teratogenic action of trypan blue in rats is due to an interference in the function of the yolk sac which is an organ of histiotrophic nutrition and provides the principal source of nutrition for the 8.5\u2010day embryo that is largely replaced by a functional chorio\u2010allantoic placenta after 11.5 days of gestation. In ferrets histiotrophic nutrition does not involve an inverted yolk sac placental system. In this species endometrial symplasma provides histiotroph which is ingested by the invading trophoblast. Histiotrophic nutrition is still of great importance at 18 days and morphological evidence indicates that chorio\u2010allantoic placentation becomes important by about 20 days (35+ somites).<\/jats:p>","DOI":"10.1002\/tera.1420180203","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:28:24Z","timestamp":1118500104000},"page":"187-191","source":"Crossref","is-referenced-by-count":11,"title":["The effect of trypan blue on the development of the ferret and rat"],"prefix":"10.1002","volume":"18","author":[{"given":"F.","family":"Beck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Swidzinska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gulamhusein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051270303"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(65)90012-3"},{"key":"e_1_2_1_4_1","first-page":"8","volume-title":"New Approaches to the Evaluation of Abnormal Embryonic Development","author":"Beck F.","year":"1975"},{"key":"e_1_2_1_5_1","first-page":"131","article-title":"The teratogenic effects of azo dyes","volume":"1","author":"Beck F.","year":"1966","journal-title":"Adv. Teratol."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420130205"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420150208"},{"key":"e_1_2_1_8_1","first-page":"159","article-title":"Light and electron microscopic observations at the pre\u2010 and early postimplantation stages in the ferret uterus","volume":"115","author":"Gulamhusein A. P.","year":"1973","journal-title":"J. Anat."},{"key":"e_1_2_1_9_1","first-page":"349","article-title":"Development and structure of the extraembryonic membranes of the ferret. A light microscopic and ultrastructural study","volume":"120","author":"Gulamhusein A. P.","year":"1975","journal-title":"J. Anat."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091410302"},{"key":"e_1_2_1_11_1","first-page":"1","article-title":"Embryonalhullen und Plazenta von Putorius furo","volume":"4","author":"Strahl H.","year":"1915","journal-title":"Abhand. K. P. Akad. Wiss."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420140310"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091330202"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420180203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420180203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T10:44:00Z","timestamp":1699785840000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420180203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,10]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1978,10]]}},"alternative-id":["10.1002\/tera.1420180203"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420180203","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,10]]}}}