{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:14:21Z","timestamp":1764688461407},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,17]],"date-time":"2005-05-17T00:00:00Z","timestamp":1116288000000},"content-version":"vor","delay-in-days":9664,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1978,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ethylenethiourea (ETU) was administered orally in single daily doses of 0, 5, 10, 30, 60 or 120 mg\/kg to time\u2010mated cats. Daily dosing was started on day 16 of gestation in all test groups and was discontinued on the appearance of toxicity signs (between days 27\u201334 of gestation) in the 120 mg\/kg group and on day 35 of gestation in the remaining test groups. Signs of toxicity, observed at all dose levels except in the 5 mg\/kg and control, were delayed in onset and characterized by progressive loss in body weight, ataxia, tremors and hind\u2010limb paralysis. A number of cats died or were killed in a moribund condition in the 30, 60 and 120 mg\/kg dose groups. Eleven of the thirty\u2010five fetuses obtained from six cats killed in a moribund state (4 from the 30 mg\/kg and 1 each from the 60\u2010 and 120 mg\/kg groups) were malformed, with coloboma occurring in four fetuses, cleft palate in two, spina bifida in one and umbilical hernia in four fetuses. Incidences of abortion and non\u2010pregnancy, both unrelated to the treatment, were found in all groups including the control. All surviving cats were necropsied on day 46 of gestation and fetuses were collected for teratologic evaluation. No clear evidence was found for teratogenicity of ETU in live fetuses.<\/jats:p>","DOI":"10.1002\/tera.1420180304","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:29:35Z","timestamp":1118500175000},"page":"311-313","source":"Crossref","is-referenced-by-count":18,"title":["Toxicity of ethylenethiourea in pregnant cats"],"prefix":"10.1002","volume":"18","author":[{"given":"K. S.","family":"Khera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Iverson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"923","article-title":"Survey of ethylenethiourea in commercial ethylenebisdithiocarbamate formulations","volume":"55","author":"Bontoyan W. R.","year":"1972","journal-title":"J. Assoc. Offic. Anal. Chem."},{"key":"e_1_2_1_3_1","first-page":"303","article-title":"Diff\u00e9rence de sensibilit\u00e9 du hamster et du rat vis\u2010\u00e0\u2010vis des effets de l'administration \u00e0 long terme de l'\u00e9thyl\u00e8ne thiour\u00e9e","volume":"9","author":"Gak J.\u2010C.","year":"1976","journal-title":"Eur. J. Toxicol."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf60187a036"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420070305"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(77)90199-5"},{"key":"e_1_2_1_7_1","first-page":"232","article-title":"Preliminary survey of ethylenethiourea residues in the Canadian food supply, 1972","volume":"8","author":"Pecka Z.","year":"1975","journal-title":"Pest. Mont. J."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420120309"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420180304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420180304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T10:40:56Z","timestamp":1699785656000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420180304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,12]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,12]]}},"alternative-id":["10.1002\/tera.1420180304"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420180304","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,12]]}}}