{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:56:18Z","timestamp":1778586978738,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,18]],"date-time":"2005-05-18T00:00:00Z","timestamp":1116374400000},"content-version":"vor","delay-in-days":9603,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1979,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Embryomortality and teratogenesis provoked by inhibitors of cholesterol synthesis are well demonstrated. Teratogenic action is particularly reflected by holoprosencephalies, but also by uro genital abnormalities. A hypercholesterolemia\u2010provoking diet has been shown to be completely effective for preventing holoprosencephaly, but only partially so for preventing the urogenital malformations and fetal mortality. It is thus possible that the two types of abnormalities are governed by different mechanisms. In addition, the diet itself, whose hypercholesterolemic effect is considerable, has certain disadvantages. It seems to have a certain effect on fetal mortality and could be responsible for several uro\u2010genital malformations. This deserves further study.<\/jats:p>","DOI":"10.1002\/tera.1420190106","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:29:17Z","timestamp":1118500157000},"page":"35-38","source":"Crossref","is-referenced-by-count":68,"title":["Teratogenic action and embryo lethality of AY 9944<sup>R<\/sup>: Prevention by a hypercholesterolemia\u2010provoking diet"],"prefix":"10.1002","volume":"19","author":[{"given":"Charles","family":"Roux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cilia","family":"Horvath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolande","family":"Dupuis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,18]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"25","article-title":"Beitrage zur Kenntnis des Cholesterine","volume":"61","author":"Burchard H.","year":"1890","journal-title":"Chem. 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G.","year":"1965"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420190106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420190106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T09:33:21Z","timestamp":1699781601000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420190106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,2]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,2]]}},"alternative-id":["10.1002\/tera.1420190106"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420190106","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,2]]}}}