{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:34:45Z","timestamp":1760204085305},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,18]],"date-time":"2005-05-18T00:00:00Z","timestamp":1116374400000},"content-version":"vor","delay-in-days":9544,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1979,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cadmium (CdSO<jats:sup>4<\/jats:sup>) was given ip on day 9 at 12 or 24 \u03bcmol\/kg to pregnant CD\u20101 (non inbred) mice. Fetuses showed malformations of the limbs, face, trunk, and tail. There was a statistically significant relationship between the dose of cadmium and the malformation rate. Cadmium (12 \u03bcmol\/kg ip on day 9) was then given to mice of six inbred strains three of which (A\/J, BALB\/ cJ, and C57BL6J) carry a gene <jats:italic>cdm<\/jats:italic> for resistance to cadmium\u2010induced testicular damage, and three strains (AKR\/J, CBA\/J, and DBA\/2J) which do not. Paradoxically, the three strains resistant to cadmium\u2010induced testicular damage were significantly more sensitive to its teratogenic effects than were the other three strains. In all inbred strains most malformations involved the limbs. All forelimb defects found in inbred or non\u2010inbred cadmium treated mice were postaxial and indistinguishable from those produced by acetazolamide in mice. The remarkable similarity of the cadmium\u2010 and acetazolamide\u2010induced forelimb malformations may be a reflection of the limited number of ways that a rodent forelimb can react to a teratogenic insult. The hindlimb defects were all preaxial.<\/jats:p>","DOI":"10.1002\/tera.1420190213","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:30:09Z","timestamp":1118500209000},"page":"229-235","source":"Crossref","is-referenced-by-count":77,"title":["Cadmium induced limb defects in mice: Strain associated differences in sensitivity"],"prefix":"10.1002","volume":"19","author":[{"suffix":"Jr.","given":"W. M.","family":"Layton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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