{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:16:27Z","timestamp":1790907387332,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,18]],"date-time":"2005-05-18T00:00:00Z","timestamp":1116374400000},"content-version":"vor","delay-in-days":9544,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1979,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pregnant rats were utilized to study the effect of maternal hyperthermia on fetal development. Eight groups of six to eight rats were exposed to ambient temperatures of 43\u201044cC at various stages of pregnancy. All rats were killed on day 20 of gestation. Edema, microencephaly and microph\u2010thalmia followed heat treatment on day 4, 6, or 8 and skeletal defects occurred on day 10 of gestation. Apparently heat stress of dams after day 14 of gestation had little or no effect on embryos. Most placentas from day 6\u201010 treatment groups were significantly heavier than control and exhibited extensive thickening and necrosis of decidua basalis. Our results suggest that the rat is a useful model for investigating maternal hyperthermia as a possible cause of human placentophathies and fetal retardation.<\/jats:p>","DOI":"10.1002\/tera.1420190216","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:30:09Z","timestamp":1118500209000},"page":"251-259","source":"Crossref","is-referenced-by-count":41,"title":["Fetal and placental responses to artificially induced hyperthermia in rats"],"prefix":"10.1002","volume":"19","author":[{"given":"K. L.","family":"Arora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. J.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R.","family":"Beaudoin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0300063"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod14.3.246"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/258604a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1968.48.4.785"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-93-5-1173"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420010206"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420020407"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)90327-3"},{"key":"e_1_2_1_10_1","first-page":"593","article-title":"Mitotic cell death and delay of mitotic activity in guinea pig embryos following brief maternal hyperthermia","volume":"32","author":"Edwards M. J.","year":"1974","journal-title":"J. Embryol. Exp. Morph."},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1152\/ajplegacy.1962.202.4.653","article-title":"Maternal influences on the fetal cardiovascular system in the sheep, dog, rabbit","volume":"202","author":"Geber W. F.","year":"1962","journal-title":"Amer. J. Physiol."},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1152\/ajplegacy.1968.214.5.979","article-title":"Evaporative water loss from rats in the heat","volume":"214","author":"Hainsworth F. R.","year":"1968","journal-title":"Amer. J. Physiol."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/1751031a0"},{"key":"e_1_2_1_14_1","first-page":"24","article-title":"Preliminary studies on the embryotoxicity of hyperthermia in the bonnet monkey (Macaca radiata)","volume":"13","author":"Hendrickx A. G.","year":"1976","journal-title":"Teratology"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420140307"},{"key":"e_1_2_1_15_1","first-page":"97","article-title":"Exencephaly in fetal hamsters following exposure to hyperthermia","volume":"19","author":"Kilham L.","year":"1976","journal-title":"Zoologica Poloniae"},{"key":"e_1_2_1_16_1","first-page":"97","article-title":"The effect of abnormal temperatures applied during the pregnancy on the structure of the vertebral column in the offspring of mammals, showed by the example white mouse. Part II. Hyperthermia","volume":"19","author":"Lecyk M.","year":"1969","journal-title":"Zoologica Poloniae"},{"key":"e_1_2_1_17_1","first-page":"45","article-title":"Does heat harm the fetus?","volume":"8","author":"Lewin R.","year":"1973","journal-title":"World Medicine."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.2307\/3627569"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(75)90087-3"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000240380"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01440962"},{"key":"e_1_2_1_22_1","volume-title":"Teratology","author":"Nielsen N. O.","year":"1969"},{"key":"e_1_2_1_23_1","first-page":"171","article-title":"Hyperthermia as a teratogenic agent","volume":"55","author":"Poswillo D.","year":"1974","journal-title":"Ann. Roy. Coll. Surg."},{"key":"e_1_2_1_24_1","first-page":"311","article-title":"Developmental abnormalities in the rat induced by heat\u2010shock","volume":"5","author":"Skreb N.","year":"1963","journal-title":"J. Embryol. Exp. Morph."}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420190216","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420190216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T10:17:15Z","timestamp":1699784235000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420190216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,4]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1979,4]]}},"alternative-id":["10.1002\/tera.1420190216"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420190216","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,4]]}}}