{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T02:06:09Z","timestamp":1768874769420,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,18]],"date-time":"2005-05-18T00:00:00Z","timestamp":1116374400000},"content-version":"vor","delay-in-days":9483,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1979,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>These studies evaluated the teratogenic potential of indole\u20103\u2010acetic acid (IAA), a naturally occurring plant hormone, in CF\u20101 mice and Sprague\u2010Dawley rats. Mice were given 5, 50, 200, or 500 mg IAA\/kg\/day by gavage on days 7 through 15 of gestation. Rats were given 50, 200, or 500 mg IAA\/kg\/day by gavage on days 7 through 15 of gestation. IAA was teratogenic in mice and rats at 500 mg\/kg\/day; cleft palate was induced in both species at this dose level. In mice, other malformations including exencephaly, ablepharia, dilated cerebral ventricles, and crooked tail were also observed. Mice given 500 mg\/kg of IAA gained less weight than control mice during gestation; no evidence of maternal toxicity was observed in rats. IAA did not cause fetal resorptions in either species and was not teratogenic at dose levels below 500 mg\/kg.<\/jats:p>","DOI":"10.1002\/tera.1420190307","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:30:27Z","timestamp":1118500227000},"page":"321-326","source":"Crossref","is-referenced-by-count":37,"title":["Teratogenic effects of the plant hormone indole\u20103\u2010acetic acid in mice and rats"],"prefix":"10.1002","volume":"19","author":[{"given":"J. A.","family":"John","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. D.","family":"Blogg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. J.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. A.","family":"Schwetz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Gehring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01796866"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02097747"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.168.3933.864"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(71)90282-1"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520292609115636"},{"issue":"1","key":"e_1_2_1_7_1","first-page":"61","article-title":"Toxicity of 2,4\u2010dichlorophenoxyacetic acid and 2,4,5\u2010trichlorophenoxyacetic acid, a report on their acute and chronic toxicity in dogs, A. M. A","volume":"7","author":"Drill V. A.","year":"1953","journal-title":"Arch. Indust. Hyg. Occup. 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E.","year":"1974","journal-title":"Teratology"},{"key":"e_1_2_1_21_1","volume-title":"Principles and Procedures of Statistics","author":"Steel R. G. D.","year":"1960"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/jn\/65.2.199","article-title":"Behavioral changes in rats and guinea pigs induced by the administration of indole\u20103\u2010acetic acid and 6\u2010aminonicotinamide","volume":"65","author":"Sullivan W. T.","year":"1958","journal-title":"J. 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