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With the use of AKR \u00d7 (C57BL\/6)(AKR)F<jats:sub>1<\/jats:sub>, and (C57BL\/6) (AKR)F<jats:sub>1<\/jats:sub> \u00d7 AKR backcrosses, it was shown that allelic differences at the <jats:italic>Ah<\/jats:italic> locus in the fetus can be correlated with dysmorphogenesis. If the mother is nonresponsive (<jats:italic>Ah<\/jats:italic><jats:sup><jats:italic>d<\/jats:italic><\/jats:sup>\/<jats:italic>Ah<\/jats:italic><jats:sup><jats:italic>d<\/jats:italic><\/jats:sup>), the <jats:italic>Ah<\/jats:italic><jats:sup><jats:italic>b<\/jats:italic><\/jats:sup>\/<jats:italic>Ah<\/jats:italic><jats:sup><jats:italic>d<\/jats:italic><\/jats:sup> genotype in the fetus is associated with more stillborns and resorptions, decreased fetal weight, increased congenital anomalies, and enhanced P<jats:sub>1<\/jats:sub>,\u2010450\u2010mediated covalent binding of BP metabolites to fetal protein and DNA, when compared with the <jats:italic>Ah<\/jats:italic><jats:sup><jats:italic>d<\/jats:italic><\/jats:sup>\/<jats:italic>Ah<\/jats:italic><jats:sup><jats:italic>d<\/jats:italic><\/jats:sup> genotype in the fetus from the same uterus. If the mother is responsive (<jats:italic>Ah<\/jats:italic><jats:sup><jats:italic>b<\/jats:italic><\/jats:sup>\/<jats:italic>Ah<\/jats:italic><jats:sup><jats:italic>d<\/jats:italic><\/jats:sup>), however, none of these parameters can be distinguished between <jats:italic>Ah<\/jats:italic><jats:sup><jats:italic>b<\/jats:italic><\/jats:sup>\/<jats:italic>Ah<\/jats:italic><jats:sup><jats:italic>d<\/jats:italic><\/jats:sup> and <jats:italic>Ah<\/jats:italic><jats:sup><jats:italic>d<\/jats:italic><\/jats:sup>\/<jats:italic>Ah<\/jats:italic><jats:sup><jats:italic>d<\/jats:italic><\/jats:sup> individuals in the same uterus, presumably because enhanced BP metabolism in maternal tissues and placenta cancels out these differences between individual fetuses.<\/jats:p><jats:p>Of particular interest in our study is the fact that the mother and the father both must be of a particular genotype before differences in teratogenesis among fetuses (due to <jats:italic>their<\/jats:italic> genotype) will be expressed. These data might provide an example in attempting to explain clinically why only one child is affected with an apparent \u201cdrug\u2010induced syndrome\u201d although the mother has taken the same dose of the particular drug during each of numerous pregnancies.<\/jats:p>","DOI":"10.1002\/tera.1420200307","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T13:10:02Z","timestamp":1118495402000},"page":"365-376","source":"Crossref","is-referenced-by-count":137,"title":["The Murine <i>Ah<\/i> locus: In utero toxicity and teratogenesis associated with genetic differences in benzo[a]pyrene metabolism"],"prefix":"10.1002","volume":"20","author":[{"given":"Shu","family":"Shum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy M.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Nebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.56.4.626"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(75)90046-1"},{"key":"e_1_2_1_4_1","first-page":"393","volume-title":"Drug Metabolism \u2013 from Microbe to Man","author":"Atlas S. 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