{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:12:22Z","timestamp":1787069542180,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,18]],"date-time":"2005-05-18T00:00:00Z","timestamp":1116374400000},"content-version":"vor","delay-in-days":9238,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1980,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Eight pregnant\n                    <jats:italic>Macaca nemestrina<\/jats:italic>\n                    were administered from 7.5 to 10 mg\/kg retinoic acid by mouth from day 20 to 44 of gestation. All fetuses exhibited craniofacial abnormalities. The craniofacial complex was studied in detail utilizing gross photography, silver nitrate impregnation, radiography, alizarin staining, and histologic processing. Nearly all the bones of the craniofacial complex were affected; the zygomatic bone and the mandible were most severly altered. Premature fusion of the coronal suture occurred in all the specimens, and there was a clockwise rotation of the craniofacial complex on right lateral view. In general, the bones of the affected fetus were smaller and less well developed than in the control specimen. The abnormal specimens in the present investigation resembled the Treacher\u2010Collins syndrome in humans, and may be the result of defective neural crest cell migration in the first and second branchial arches.\n                  <\/jats:p>","DOI":"10.1002\/tera.1420210105","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T20:13:18Z","timestamp":1118520798000},"page":"29-38","source":"Crossref","is-referenced-by-count":53,"title":["The effect of high doses of retinoic acid on prenatal craniofacial development in\n                    <i>Macaca nemestrina<\/i>"],"prefix":"10.1002","volume":"21","author":[{"given":"Janice E.","family":"Yip","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent G.","family":"Kokich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Shepard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(70)90143-0"},{"key":"e_1_2_1_3_1","first-page":"13","article-title":"Prenatal mandibulofacial dysostosis (Treacher\u2010Collins Syndrome)","volume":"14","author":"Behrents R. G.","year":"1977","journal-title":"Cleft Palata J."},{"key":"e_1_2_1_4_1","first-page":"9","article-title":"The premature synostosis of the cranial sutures","volume":"51","author":"Bertelsen T. I.","year":"1958","journal-title":"Acta Opthalmol. (Suppl.)"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.13.6.556"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345590380010701"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420150109"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098586500200502"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091160308"},{"key":"e_1_2_1_10_1","first-page":"143","article-title":"Experimental production of congenital malformations in the Japanese white rabbits by maternal treatment with hypervitaminosis A","volume":"9","author":"Itabashi M.","year":"1969","journal-title":"Cong. Anom."},{"key":"e_1_2_1_11_1","first-page":"1","volume-title":"Birth Defects: Original Article Series","author":"Johnston M. C.","year":"1977"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1960.tb49947.x"},{"key":"e_1_2_1_13_1","first-page":"1","article-title":"Experimental production of congenital malformations in strains of inbred mice by maternal treatment with hypervitaminosis A","volume":"38","author":"Kalter H.","year":"1961","journal-title":"Am. J. 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New method for alizarin preparation to keep the material clear and hard."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1962.03050490004002"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197902153000701"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-117X(75)90019-0"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420050115"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19650029"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/188672b0"},{"key":"e_1_2_1_27_1","first-page":"104","article-title":"Use of rhesus monkeys in teratological studies","volume":"30","author":"Wilson J. G.","year":"1971","journal-title":"Fed. Proc."},{"key":"e_1_2_1_28_1","first-page":"191","volume-title":"Proceedings of the fourth internationla conference on birth defects","author":"Wilson J. G.","year":"1973"},{"key":"e_1_2_1_29_1","first-page":"171","article-title":"Vitamin\u2010A deficiency and excess in relation to skeletal growth","volume":"29","author":"Wolbach S. B.","year":"1947","journal-title":"J. Bone Joint Surg."},{"key":"e_1_2_1_30_1","first-page":"30","article-title":"Hypervitaminosis A and the skeleton of growing chicks","volume":"54","author":"Wolbach S. B.","year":"1952","journal-title":"Arch. Pathol."},{"key":"e_1_2_1_31_1","first-page":"1009","article-title":"Bone lesions of hypervitaminosis A in the pig","volume":"29","author":"Wolke R. E.","year":"1968","journal-title":"Am. J. Vet. Res."}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420210105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420210105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T07:33:05Z","timestamp":1699774385000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420210105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,2]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1980,2]]}},"alternative-id":["10.1002\/tera.1420210105"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420210105","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,2]]}}}