{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T18:28:04Z","timestamp":1721586484069},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,18]],"date-time":"2005-05-18T00:00:00Z","timestamp":1116374400000},"content-version":"vor","delay-in-days":9238,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1980,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fetal mouse tissue was investigated for a glucocorticoid binding receptor which might be responsible for cleft palate formation. Fetal mouse heads contain a soluble component which binds the glucocorticoid triamcinolone acetonide in vitro with high affinity. This binding component is present in small finite amounts. Other glucocorticoids compete with triamcinolone acetonide for the binding site in a manner consistent with their potency ranking as cleft palate teratogens. Several mineralocorticoids and progestins also compete when administered in vitro but not when administered in vivo. Triamcinolone acetonide binding was determined in three mouse strains, A\/J C3H, and C57BL, which are listed in decreasing order of cleft palate susceptibility to cortisone. No positive correlation was found between cortisone cleft palate susceptibility and either triamcinolone acetonide binding affinity or binding amout in fetuses from these strains. Cleft palate dose response curves for triamcinolone acetonide were determined in these strains, but they were not parallel to each other as they were for cortisone. This suggests that triamcinolone acetonide may cause cleft palate by different mechanisms in these strains. Thus, fetal mouse tissue contains and apparent glucocorticoid receptor, but its relationship to cleft palate formation in mice is not clear.<\/jats:p>","DOI":"10.1002\/tera.1420210106","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:13:18Z","timestamp":1118535198000},"page":"39-51","source":"Crossref","is-referenced-by-count":32,"title":["A glucocorticoid receptor in fetal mouse: Its relationship to cleft palate formation"],"prefix":"10.1002","volume":"21","author":[{"given":"John F.","family":"Hackney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420070208"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420150104"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.5.932"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/genetics\/84.4.743","article-title":"Genetics of cortisoneinduced cleft palate in the mouse\u2010embryonic and maternal effects","volume":"84","author":"Biddle F. 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