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The observation that palatal shelves of excess witamin A exposed fetuses are stunted and delayed in rotation suggests that vitamin A may inhibit a biochemical event crucial to the successful contact of the palatal shelves. Maxillary explants from 16 day Wistar rat embryos cultured in the presence or absence of 30 IU\/ml retinyl palmitate were analyzed for DNA, glycosaminoglycan, and collagen synthesis. Maxillary explants cultured in vitamin A\u2010containing medium showed an inhibition in DNA, GAG, and collagen synthesis in comparison to control explants. Excess vitamin A in the culture medium of maxillary explants also resulted in a reduction of intermolecular cross\u2010links in collagen. The possible significance of the results in terms of cleft palate and normal secondary palate formation is discussed.<\/jats:p>","DOI":"10.1002\/tera.1420210117","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:13:18Z","timestamp":1118535198000},"page":"123-130","source":"Crossref","is-referenced-by-count":11,"title":["Hypervitaminosis A and matrix alterations in maxillary explants from 16\u2010day rat embryos"],"prefix":"10.1002","volume":"21","author":[{"given":"George J. 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