{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:33:18Z","timestamp":1762144398406},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T00:00:00Z","timestamp":1116460800000},"content-version":"vor","delay-in-days":8873,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1981,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several compounds were administered to pregnant Wistar\u2010de\u2010rived rats either 24 or four hours prior to the recovery of day 10 embryos for in vitro culture in Waymouth's medium and fetal calf serum. The compounds tested were 2\u2010amino\u2010l,3,4,\u2010thiadiazole (thiadiazole), cadmium sulfate, l,2\u2010dibromo\u20102,2\u2010dichloroethyl dimethyl phosphate (dibrom), 2\u2010(sec\u2010Butyl)\u20104,6\u2010dinitrophenol (di\u2010noseb), lead nitrate, polybrominated biphenyls (PBB), sodium arsenate, and trypan blue. After 24 hours in culture, two thirds of the embryos were recovered for examination. The remaining one third were continued in culture until 42 hours. Recovered embryos were examined for rotation of the embryonic axis, heart rate, establishment of the visceral yolk sac circulation, somite number, growth of the limb buds, closure of the neural tube, and development of the allantois and amnion. All tested compounds inhibited the rate of development in vitro.<\/jats:p>","DOI":"10.1002\/tera.1420230108","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:36:47Z","timestamp":1118500607000},"page":"57-61","source":"Crossref","is-referenced-by-count":39,"title":["An in vivo\/in vitro evaluation of teratogenic action"],"prefix":"10.1002","volume":"23","author":[{"given":"Allan R.","family":"Beaudoin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Lowell","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420070110"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420100211"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(77)90069-X"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.157.3793.1180"},{"key":"e_1_2_1_6_1","first-page":"47","article-title":"A preliminary report on hydrocephalus, spina bifida and other congenital anomalies in the rat produced by trypan blue","volume":"13","author":"Gillman J.","year":"1948","journal-title":"S. Afr. J. Med. Sci."},{"key":"e_1_2_1_7_1","first-page":"307","article-title":"Recherches sur la culture des oeufs des mammif%res","volume":"34","author":"Jolly J.","year":"1938","journal-title":"Arch. Anat. Microsc. Morphol. Exp."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420110307"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(75)90053-8"},{"key":"e_1_2_1_10_1","first-page":"305","volume-title":"Methods in Mammalian Embryology","author":"New D. A. T.","year":"1971"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-185X.1978.tb00993.x"},{"key":"e_1_2_1_12_1","first-page":"227","article-title":"Development of a placental blood circulation in rat embryos in vitro","volume":"37","author":"New D. A. T.","year":"1977","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_13_1","first-page":"133","article-title":"Comparision of growth in vitro and in vivo of post\u2010implantation rat embryos","volume":"36","author":"New D. A. T.","year":"1976","journal-title":"J. Embryol. Exp. 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G.","year":"1978"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420230108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420230108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T09:34:37Z","timestamp":1699781677000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420230108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,2]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,2]]}},"alternative-id":["10.1002\/tera.1420230108"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420230108","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,2]]}}}