{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:29:03Z","timestamp":1760887743527},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T00:00:00Z","timestamp":1116460800000},"content-version":"vor","delay-in-days":8753,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1981,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intraperitoneal injection of BUdR on day 11 or 12 of rat gestation produced preaxial polydactyly of the hindlimb. The pathogenesis of this deformity differed from that of other polydactyly regimes in that drug\u2010induced mesenchymal necrosis was not an essential feature. Likewise an altered pattern of physiological necrosis in the apical ectodermal ridge (AER) was not evident in hindlimbs of BUdR\u2010treated embryos. In keeping with earlier studies, a zone of physiological necrosis within the preaxial mesoderm thought to be instrumental in controlling preaxial digitation was abolished. Speculation has focused on the incorporation of BUdR into these prospectively necrotic cells as the means by which they survive. Support for this idea is gained from the protective effect of concomitant thymidine administration, which presumably prevents BUdR incorporation.<\/jats:p>","DOI":"10.1002\/tera.1420230313","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:38:02Z","timestamp":1118500682000},"page":"383-389","source":"Crossref","is-referenced-by-count":28,"title":["Pathogenesis of bromodeoxyuridine\u2010induced polydactyly"],"prefix":"10.1002","volume":"23","author":[{"given":"William J.","family":"Scott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"623","article-title":"Direct exposure of post\u2010implantation mouse embryos to 5\u2010bromodeoxyuridine in vitro and its effect on subsequent chondrogenesis in the limbs","volume":"36","author":"Agnish N.","year":"1976","journal-title":"J. Embryol. Exp. 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