{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T06:35:26Z","timestamp":1760423726369},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T00:00:00Z","timestamp":1117497600000},"content-version":"vor","delay-in-days":8520,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1982,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adult toxicity, embryo lethality, and teratogenicity of cytochalasins D and E (CD and CE) were determined for A\/J, C57BL\/6J, a<jats:sup>e<\/jats:sup>a<jats:sup>e<\/jats:sup>, and OELN mouse strains. The adult LD<jats:sub>50<\/jats:sub> for CD (1.9\u20132.6 mg\/kg) and CE (3.1\u20133.3) were similar for the strains. Although adult LD<jats:sub>50<\/jats:sub>s were similar, the embryo lethality and teratogenicity of CD and CE vary from strain to strain when all were treated with intraperitoneal injections on days 7\u20139 of gestation. CD was more teratogenic than CE and frequently produced exencephaly while CE did not. CD was more teratogenic in OELN and a<jats:sup>e<\/jats:sup>a<jats:sup>e<\/jats:sup> (ED<jats:sub>50<\/jats:sub> \u00b1 0.7 mg\/kg) than in A\/J or C57BL\/6J (ED<jats:sub>50<\/jats:sub> &gt; 1.2 mg\/kg). OELN fetuses were more resistant to lethal effects of CD than the other strains which had fetal LD<jats:sub>50<\/jats:sub>s \u00b1 1.2 mg\/kg maternal weight. The F<jats:sub>1<\/jats:sub> fetuses of a cross of sensitive a<jats:sup>e<\/jats:sup>a<jats:sup>e<\/jats:sup> and resistant C57BL\/6J showed intermediate sensitivity to exencephaly. The results suggest a genetic contribution to the response and differences in action of CD and CE as teratogens.<\/jats:p>","DOI":"10.1002\/tera.1420250103","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:41:02Z","timestamp":1118500862000},"page":"11-18","source":"Crossref","is-referenced-by-count":21,"title":["Differences in the toxicity and teratogenicity of cytochalasins D and E in various mouse strains"],"prefix":"10.1002","volume":"25","author":[{"given":"W. 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