{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:06:09Z","timestamp":1768453569210,"version":"3.49.0"},"reference-count":76,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T00:00:00Z","timestamp":1117497600000},"content-version":"vor","delay-in-days":8461,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1982,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The craniofacial anatomy of an infant with facial duplication is described. There were four eyes, two noses, two maxillae, and one mandible. Anterior to the single pituitary the brain was duplicated and there was bilateral arhinencephaly. Portions of the brain were extruded into a large frontal encephalocele. Cases of symmetrical facial duplication reported in the literature range from two complete faces on a single head (diprosopus) to simple nasal duplication. The variety of patterns of duplication suggests that the doubling of facial components arises in several different ways: Forking of the notochord, duplication of the prosencephalon, duplication of the olfactory placodes, and duplication of maxillary and\/or mandibular growth centers around the margins of the stomatodeal plate. Among reported cases, the female:male ratio is 2:1.<\/jats:p>","DOI":"10.1002\/tera.1420250205","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:41:21Z","timestamp":1118500881000},"page":"153-159","source":"Crossref","is-referenced-by-count":51,"title":["Facial duplication: Case, review, and embryogenesis"],"prefix":"10.1002","volume":"25","author":[{"suffix":"Jr.","given":"Mason","family":"Barr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,31]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Die Missbildungen des Menschen","author":"Ahlfeld A.","year":"1880"},{"key":"e_1_2_1_3_1","unstructured":"Aldrovandi U.(1642)Monstrorum Historia Bononiae. Ch. III. p.454. Cited by Taruffi (1882)."},{"key":"e_1_2_1_4_1","unstructured":"Ammiano M.(1681)Rerum Gestarum. Parisis. Book 19 Ch. XII. Cited by Taruffi (1882)."},{"key":"e_1_2_1_5_1","first-page":"506","article-title":"Duplication of oral structures with cleft palate","volume":"6","author":"Avery J. K.","year":"1969","journal-title":"Cleft Palate J."},{"key":"e_1_2_1_6_1","first-page":"292","article-title":"A rare case of duplicitas anterior","volume":"98","author":"Bacsich P.","year":"1964","journal-title":"J. Anat."},{"key":"e_1_2_1_7_1","first-page":"171","article-title":"Sur une difformit\u00e9 rare de la t\u011bte et de l' enc\u00e9phale","volume":"3","author":"Bimar","year":"1881","journal-title":"Gaz. Hebd. Sci. Med. Montpellier"},{"key":"e_1_2_1_8_1","volume-title":"Descrizione d'una rnonstruosa bambina","author":"Bongiovanni Z.","year":"1789"},{"key":"e_1_2_1_9_1","first-page":"140","volume":"15","author":"Bordenave T.","year":"1761","journal-title":"Roux J. Med."},{"key":"e_1_2_1_10_1","unstructured":"Borelli P.(1670) Cited by Rating ('33)."},{"key":"e_1_2_1_11_1","first-page":"761","article-title":"An anencephalic monster with \u201crhinodymie\u201d and other anomalies","volume":"11","author":"Broder S. B.","year":"1935","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_12_1","unstructured":"Brugisser(1881)C.R. Soc. Helv. p.100. Cited by Taruffi (1882)."},{"key":"e_1_2_1_13_1","unstructured":"Buch J. A.(1866) De Monstro Humano Distomo.Inaug. Diss. Halle.Cited by Broder ('35)."},{"key":"e_1_2_1_14_1","first-page":"312","volume-title":"Klinik der Geburtskunde","author":"Buhl L.","year":"1861"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01995231"},{"key":"e_1_2_1_16_1","first-page":"453","volume-title":"Istoria della Generazione","author":"Caccia G.","year":"1721"},{"key":"e_1_2_1_17_1","first-page":"392","article-title":"Craniofacial duplication (diprosopus) in a twin","volume":"100","author":"Changaris D. G.","year":"1976","journal-title":"Arch. Pathol. Lab. Med."},{"key":"e_1_2_1_18_1","first-page":"356","article-title":"Miscell","volume":"1","author":"Chilian B.","year":"1682","journal-title":"Naturae Curios., Dec. 2, Ann"},{"key":"e_1_2_1_19_1","first-page":"329","article-title":"\u00dcber eine diprosopie bei geschlossenen neurocranium","volume":"95","author":"Clausnitzer K. H.","year":"1956","journal-title":"Zentrabl. Allg. Pathol."},{"key":"e_1_2_1_20_1","first-page":"117","article-title":"Frontonasal dysplasia (median cleft face syndrome)","volume":"7","author":"Cohen M. M.","year":"1971","journal-title":"Birth Defects"},{"key":"e_1_2_1_21_1","first-page":"360","volume":"1","author":"Cruveilhier J.","year":"1849","journal-title":"Trait\u00e9 d' Anatomie Pathologique"},{"key":"e_1_2_1_22_1","unstructured":"D'Alton E.(1853)De monstris qui extremitatis superfluae suspensae sunt. Halis p.43. Cited by Taruffi (1882)."},{"key":"e_1_2_1_23_1","first-page":"992","article-title":"Monstre de la classe des monomphaliens","volume":"20","author":"Depaul","year":"1855","journal-title":"Paris: Bull. Acad. Med."},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-196202000-00003"},{"key":"e_1_2_1_25_1","first-page":"783","volume-title":"Birth Defects Compendium","author":"Erich J. B.","year":"1979"},{"key":"e_1_2_1_26_1","first-page":"268","article-title":"Muller Arch","volume":"1","author":"Eschricht","year":"1834","journal-title":"Physiol. Wissen. Med."},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02204746"},{"key":"e_1_2_1_28_1","volume-title":"Die Missbildungen des Menschen Systematisch Dargestellt","author":"Foerster A.","year":"1865"},{"key":"e_1_2_1_29_1","first-page":"331","article-title":"Congenital anomalies of the floor of the mouth and of the mandible","volume":"8","author":"Fontaine S. B.","year":"1950","journal-title":"J. Oral Surg."},{"key":"e_1_2_1_30_1","first-page":"195","volume-title":"Trait\u00e9 de Teratologic","author":"Geoffroy Saint\u2010Hilaire I.","year":"1836"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100074284"},{"key":"e_1_2_1_32_1","first-page":"285","article-title":"Syst\u00e8me chordal et morphogenese de la t\u011bte chez l'embryon normal et chez les monstres doubles","volume":"42","author":"Giroud A.","year":"1959","journal-title":"Arch. Anat. Histol. Embryol. (Strosb.)"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-196401000-00008"},{"key":"e_1_2_1_34_1","first-page":"26","volume-title":"Ragionamento in occasione d'un acranico","author":"Grillo A.","year":"1813"},{"key":"e_1_2_1_35_1","volume-title":"\u00dcber ein diprosopus triophtalmus","author":"Gronau L.","year":"1864"},{"key":"e_1_2_1_36_1","first-page":"240","article-title":"Beitr\u00e4ge zur kenntis der dicephalie","volume":"77","author":"Gruber G. B.","year":"1927","journal-title":"Beitr. Pathol. Anat."},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80759-3"},{"key":"e_1_2_1_38_1","first-page":"650","article-title":"Die doppelbildungen des menschen und der tiere","volume":"15","author":"H\u00fcbner H.","year":"1911","journal-title":"Erg. Allg. Pathol. Anat."},{"key":"e_1_2_1_39_1","first-page":"23","article-title":"Some abnormal patterns of development in the craniofacial region","volume":"15","author":"Johnston M. C.","year":"1979","journal-title":"Birth Defects"},{"key":"e_1_2_1_40_1","unstructured":"Joly(1857). Cited by Rating ('33)."},{"key":"e_1_2_1_41_1","first-page":"204","article-title":"Zwischenkiefer verdoppelung mit normotoper und heterotoper zahn\u00fcberzahl sowie gaumenspalte","volume":"54","author":"Koblin I.","year":"1970","journal-title":"Dtsch. Zahn\u2010Mund\u2010Kieferheilk."},{"key":"e_1_2_1_42_1","first-page":"70","volume":"1","author":"Lancereaux E.","year":"1875","journal-title":"Trait\u00e9 d'Anatomie Pathologique"},{"key":"e_1_2_1_43_1","first-page":"329","article-title":"Di un raro caso di naso doppio congenito","volume":"28","author":"Lasagna F.","year":"1917","journal-title":"Arch. Ital. Otolaryngol. Rinol. Laryngol."},{"key":"e_1_2_1_44_1","first-page":"22","article-title":"Diprosopus","volume":"28","author":"Latteier K. K.","year":"1952","journal-title":"Med. Radiogr. Photogr."},{"key":"e_1_2_1_45_1","unstructured":"Ledel S.(1687)Ephem. Naturae Curios.Dec. 2 Ann 6 p.152(Obs. 64). Cited by Taruffi (1882)."},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01878024"},{"key":"e_1_2_1_47_1","first-page":"105","article-title":"Contribution \u00e0 l'\u00e9tude des monstres polygnathiens","volume":"46","author":"Lesbre F. X.","year":"1910","journal-title":"J. Anat. Physiol"},{"key":"e_1_2_1_48_1","first-page":"501","article-title":"Giorn","volume":"52","author":"Macari F.","year":"1865","journal-title":"R. Acad. Med. Torino, Ser 2a"},{"key":"e_1_2_1_49_1","first-page":"702","article-title":"Description of a diprosopus triophthalmus monster","volume":"20","author":"MacDonald","year":"1875","journal-title":"Edinb. Med. J."},{"key":"e_1_2_1_50_1","first-page":"573","article-title":"Congenital malformations in the frontonasal area","volume":"5","author":"Mazzola R. F.","year":"1976","journal-title":"Clin. Plast. Surg."},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-185701000-00005"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.32.162.135"},{"key":"e_1_2_1_53_1","first-page":"8","article-title":"Case of double nose","volume":"17","author":"Muecke F. F.","year":"1923","journal-title":"Proc. R. Soc. Med. Sect. Laryngol."},{"key":"e_1_2_1_54_1","volume-title":"De monstro quodam humano","author":"Noodt G. W.","year":"1839"},{"key":"e_1_2_1_55_1","first-page":"401","article-title":"A case of double formation of the face with cranioschisis","volume":"48","author":"Onof B.","year":"1895","journal-title":"Med. Rec."},{"key":"e_1_2_1_56_1","volume-title":"Monstrorum sexcentorum descriptio anatomica","author":"Otto A.","year":"1841"},{"key":"e_1_2_1_57_1","first-page":"165","volume-title":"Morborum Vulgarum Historia","author":"Pestalozzi G. G.","year":"1722"},{"key":"e_1_2_1_57_2","first-page":"122","volume":"14","author":"Pestalozzi","journal-title":"Observations sur la physique"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01892772"},{"key":"e_1_2_1_59_1","first-page":"114","volume-title":"La Scienza e la Pratica","author":"Sangalli G.","year":"1875"},{"key":"e_1_2_1_60_1","first-page":"595","volume":"2","author":"Sirena Santi","year":"1872","journal-title":"Enciclopedia Med. Ital."},{"key":"e_1_2_1_61_1","first-page":"302","article-title":"Ephem","volume":"3","author":"Scelhas E. F.","year":"1864","journal-title":"Naturae Curios."},{"key":"e_1_2_1_62_1","first-page":"283","volume-title":"Die Morphologie der Missbildungen der Menschen und der Tiere","author":"Schwalbe E.","year":"1907"},{"key":"e_1_2_1_63_1","first-page":"866","article-title":"Mem","volume":"25","author":"Seres","year":"1860","journal-title":"Acad. Sci. Paris"},{"key":"e_1_2_1_64_1","volume-title":"Abbildungen und Beschribungen einiger Missgeburten","author":"Soemmering S. T.","year":"1791"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.116.3.598"},{"key":"e_1_2_1_66_1","unstructured":"Swayne J. G.(1867)Trans. Obstet. Soc. Lond. 8. Cited by Taruffi (1882)."},{"key":"e_1_2_1_67_1","first-page":"488","volume-title":"Storia della Teratologia","author":"Taruffi C.","year":"1882"},{"key":"e_1_2_1_68_1","volume-title":"Feto umano con due mandibole simmetriche","author":"Taruffi C.","year":"1892"},{"key":"e_1_2_1_69_1","volume-title":"Zeichnungen von Missgeburten der Moskauer Sammlung","author":"Von Asch L. B."},{"issue":"3","key":"e_1_2_1_70_1","first-page":"134","volume":"6","author":"Von Lenhossek","year":"1821","journal-title":"Med. Jahrb. Oest. Staats"},{"key":"e_1_2_1_71_1","unstructured":"Vrolik V.(1849)Tabulae ad illustrandem embryogenesis hominis et mammalium tam naturalem quam abnormalem. Amsterdam. Cited by Foerster (1865)."},{"key":"e_1_2_1_72_1","first-page":"1","volume":"4","author":"Vrolik V.","year":"1856","journal-title":"Kanstatt Jahresbericht"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02956726"},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000080113"},{"key":"e_1_2_1_75_1","first-page":"219","article-title":"Three cases of malformations connected with the face","volume":"4","author":"Windle B. C. A.","year":"1889","journal-title":"Anat. Anz."},{"key":"e_1_2_1_76_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100023938"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420250205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420250205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T09:38:55Z","timestamp":1699781935000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420250205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,4]]},"references-count":76,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1982,4]]}},"alternative-id":["10.1002\/tera.1420250205"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420250205","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,4]]}}}