{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:42:46Z","timestamp":1757544166924},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T00:00:00Z","timestamp":1117497600000},"content-version":"vor","delay-in-days":8400,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1982,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Female CD\u20101 mice were mated with CD\u20101 \u00d7 <jats:italic>T<\/jats:italic>\/ + F<jats:sub>1<\/jats:sub> males that were heterozygous for the brachyury (<jats:italic>T<\/jats:italic>) semidominant lethal gene or were +\/+. Fetuses from CD\u20101 \u00d7 +\/ + matings were normal when observed on gestation Day 17 (plug day = Day 0). Those from the CD\u20101 \u00d7 <jats:italic>T<\/jats:italic>\/+ cross exhibited the expected 1:1 ratio of short:normal tail lengths, but 10% of these fetuses were tailless, apparently due to factors in the CD\u20101 genotype that increased the expressivity of the <jats:italic>T<\/jats:italic>\u2010gene with regard to reduction of tail length. Additional CD\u20101 females were mated with CD\u20101 \u00d7 <jats:italic>t<\/jats:italic><jats:sup>w18<\/jats:sup>\/+ F<jats:sub>1<\/jats:sub> males. Fetuses from the CD\u20101 \u00d7 <jats:italic>t<\/jats:italic><jats:sup>w18<\/jats:sup>\/+ matings were normal. CD\u20101 females carrying CD\u20101 X +\/+, CD\u20101 \u00d7 <jats:italic>T<\/jats:italic>\/+, or CD\u20101 \u00d7 <jats:italic>t<\/jats:italic><jats:sup>w18<\/jats:sup>\/ + litters were injected ip on gestation Day 9 with 30 mg\/kg cycloheximide or were untreated. Cycloheximide was teratogenic for litters from all three crosses. Polydactyly, oligodactyly, and a variety of skeletal abnormalities were observed. Gross malformations and total skeletal malformations were increased in treated CD\u20101 \u00d7 <jats:italic>T<\/jats:italic>\/ + or <jats:italic>t<\/jats:italic><jats:sup>w18<\/jats:sup>\/ + litters in comparison with CD\u20101 \u00d7 +\u2010\/ + litters, as were nonvertebral skeletal defects in CD\u20101 \u00d7 <jats:italic>t<\/jats:italic><jats:sup>w18<\/jats:sup>\/+ litters. Prenatal mortality was also greater in treated mutant\u2010containing litters than in + \/ + litters, and fetal weights were similarly decreased in treated CD\u20101 \u00d7 <jats:italic>t<\/jats:italic><jats:sup>w18<\/jats:sup>\/ + litters. The incidence of taillessness was also higher in treated (26%) than in control (10%) CD\u20101 \u00d7 <jats:italic>T<\/jats:italic> \/ + litters. Thus both the <jats:italic>T<\/jats:italic> and <jats:italic>t<\/jats:italic><jats:sup>w18<\/jats:sup> alleles appear to have enhanced the teratogenicity of cycloheximide, and the inhibitor may have increased the expressivity of <jats:italic>T<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/tera.1420250311","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:41:04Z","timestamp":1118500864000},"page":"345-349","source":"Crossref","is-referenced-by-count":8,"title":["Interactions between cycloheximide and <i>T<\/i>\u2010locus alleles during mouse embryogenesis"],"prefix":"10.1002","volume":"25","author":[{"given":"Joseph M.","family":"Lary","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald D.","family":"Hood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Lindahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,31]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/256545a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(75)90033-1"},{"key":"e_1_2_1_4_1","first-page":"207","volume-title":"The Early Development of Mammals","author":"Bennett D.","year":"1975"},{"key":"e_1_2_1_5_1","first-page":"247","volume-title":"Proceedings of the Third Lepetit Colloquium, Cell Interactions","author":"Bennett D.","year":"1972"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520296209114589"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.1.30"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420140302"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(76)90154-8"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091190402"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420030203"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420170108"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.11.4080"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02157680"},{"key":"e_1_2_1_15_1","first-page":"400","article-title":"The analysis of variance and the analysis of causes","volume":"26","author":"Lewontin R. 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