{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:21:11Z","timestamp":1789388471049,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T00:00:00Z","timestamp":1117497600000},"content-version":"vor","delay-in-days":8400,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1982,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Murine trisomy (Ts) 16 occurs in the fetal and neonatal progeny of males doubly heterozygous for the Robertsonian metacentric chromosomes Rb(16.17)7Bnr\/Rb(9.16)9Rma and \u201call acrocentric\u201d females. The developmental aspects of this trisomy were studied between day 12 of gestation and birth. So far, postnatal survival longer than a few hours after birth has not been observed. The frequency of Ts 16 among all implants decreased from more than 20% on day 14 to values between 4% and 7% shortly before term.<\/jats:p><jats:p>Main features of Ts 16 are moderate general hypoplasia, slight developmental retardation, and cardiovascular anomalies. These latter were found in 96% of the trisomies, the great majority belonging to the transposition type, i.e., riding aorta, double outlet right ventricle (DORV) and transposition of the great arteries (TGA). Association with common atrio ventricular (AV)\u2010canal was frequent. Other anomalies as \u201copen eyelid\u201d, hydronephrosis, and hydroureter seem to be attributable to the effects of retardation. Generalized transient edema was frequent in the later gestational stages of Ts 16.<\/jats:p><jats:p>Severe cardiovascular malformation is possibly one of the factors responsible for late fetal or neonatal death in some cases. Another factor probably contributing to Ts 16 fetal mortality is insufficiency of placental function due to hypoplasia of the fetal vasculature of this organ. The teratological study of Ts 16 demands interest since evidence has been forwarded to consider this trisomy as an animal model of human trisomy 21.<\/jats:p>","DOI":"10.1002\/tera.1420250314","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:41:04Z","timestamp":1118500864000},"page":"369-380","source":"Crossref","is-referenced-by-count":112,"title":["Trisomy 16 in the mouse fetus associated with generalized edema and cardiovascular and urinary tract anomalies"],"prefix":"10.1002","volume":"25","author":[{"given":"Shinichi","family":"Miyabara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Gropp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Winking","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,31]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000130462"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.4.2168"},{"key":"e_1_2_1_4_1","first-page":"145A","article-title":"Chromosomal assignment of mouse PRGS: Further evidence for homology between mouse chromosome 16 and human chromosome 21","volume":"33","author":"Cox D. R.","year":"1981","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_2_1_5_1","volume-title":"Cytogenetics of mammalian development (Russian)","author":"Dyban A. P.","year":"1978"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-68006-9_12"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.10.5230"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-8933-4_7"},{"key":"e_1_2_1_9_1","first-page":"22","article-title":"Research note","volume":"63","author":"Groh\u00e9 G.","year":"1980","journal-title":"Mouse News Lett, (on Ts 19)"},{"key":"e_1_2_1_10_1","first-page":"539","article-title":"Animal Model: Autosomal trisomies in fetal mice. Excencephaly in mice with trisomy 12","volume":"77","author":"Gropp A.","year":"1974","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_11_1","first-page":"85","article-title":"Relevance of phases of development for expression of abnormality: Perspectives drawn from experimentally induced chromosome aberrations","volume":"10","author":"Gropp A.","year":"1978","journal-title":"Berlin: Dahlem\u2010Konferenzen \u2010 Life Sci Rep"},{"key":"e_1_2_1_12_1","unstructured":"Gropp A.andG.Groh\u00e9(1981)Strain background dependence of expression of chromosome triplication in the mouse embryo. Proc. Workshop of Molecular Genetics of the Mouse II. S\u00f8derborg\/ Denmark Aug.11\u201316 1980."},{"key":"e_1_2_1_12_2","first-page":"7","volume":"94","journal-title":"Hereditas"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000130304"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000130318"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-66458-8_12"},{"key":"e_1_2_1_16_1","first-page":"141","volume-title":"Biology of the House Mouse","author":"Gropp A.","year":"1981"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","unstructured":"Hongell K.andA.Gropp(1981) Trisomy 13 in the mouse.Teratology in press.","DOI":"10.1002\/tera.1420260113"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672300015226"},{"key":"e_1_2_1_19_1","first-page":"1820","volume-title":"Pathology of laboratory animals","author":"Kalter H.","year":"1978"},{"key":"e_1_2_1_20_1","first-page":"166","article-title":"A study of mouse Ts 16 associated with generalized edema and cardiovascular and urinary anomalies. (Abstract)","volume":"20","author":"Miyabara S.","year":"1979","journal-title":"Teratology"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-8933-4_15"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091560206"},{"key":"e_1_2_1_23_1","first-page":"119","volume-title":"Handbook of Teratology","author":"Nishimura H.","year":"1977"},{"key":"e_1_2_1_24_1","volume-title":"Congenital anomalies of the heart","author":"Okamoto N.","year":"1980"},{"key":"e_1_2_1_25_1","first-page":"169","article-title":"Effects of fast neutron irradiation on the developing rat embryo","volume":"17","author":"Okamoto N.","year":"1968","journal-title":"J. Med. Sci., Hiroshima"},{"key":"e_1_2_1_26_1","first-page":"389","article-title":"Congenital heart disease in experimental (fetal) mouse trisomies: Incidence","volume":"5","author":"Pexieder T.","year":"1981","journal-title":"Perspec. Cardiovasc. Res."},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","unstructured":"Polani P. E.(1974) Chromosomal and other genetic influences on birth weight variation. In: Size at Birth. K. Elliot and J. Knight eds.Ciba Found. Symp. 27:127\u2013164.","DOI":"10.1002\/9780470720097.ch8"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1980.tb04331.x"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00432645"},{"key":"e_1_2_1_30_1","first-page":"897","volume-title":"Heart Disease in Infancy and Childhood","author":"Rowe R. 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