{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T05:40:32Z","timestamp":1699767632058},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T00:00:00Z","timestamp":1116460800000},"content-version":"vor","delay-in-days":8327,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1982,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>D\u2010penicillamine, added to a low copper diet fed through pregnancy or given by gavage to pregnant rats which were on a copper\u2010deficient or a normal diet produced fetal resorptions and malformations. Doses of 300 to 400 mg per day for 6 days (days 9\u201314 of gestation) with a diet normal for copper prevented maternal weight gain and at 350 or 400 mg\/day caused fetal death on day 16 or 17. Forty percent of offspring had tracheobronchomegaly and 42% had cystic lungs. Associated abnormalities included pleural hemorrhages, dilated esophagi, and unaerated lungs. The lungs had large, poorly formed, thick\u2010walled acini without partitioning and a thick rim of connective tissue around vessels and bronchi. At the higher doses, all members of one of 12 litters had angulation of the spine and half the members of another litter had cleft palates. A postulated mechanism for these alterations in pulmonary connective tissue productive of malformations which model human tracheobronchomegaly and cystic lungs, is interference with lysyl oxidase, a copper\u2010requiring enzyme, which cross\u2010links elastin.<\/jats:p>","DOI":"10.1002\/tera.1420260102","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:42:12Z","timestamp":1118500932000},"page":"1-9","source":"Crossref","is-referenced-by-count":15,"title":["Neonatal deaths and pulmonary dysplasia due to D\u2010penicillamine in the rat"],"prefix":"10.1002","volume":"26","author":[{"given":"Kaye H.","family":"Kilburn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rex A.","family":"Hess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"661","article-title":"Penicillamine nephropathy in rheumatoid arthritis. A clinical, pathological and immunological study","volume":"45","author":"Bacon P. A.","year":"1976","journal-title":"Q. J. Med."},{"key":"e_1_2_1_3_1","first-page":"293","article-title":"An x\u2010linked form of cutis laxa due to deficiency of lysyl oxidase","volume":"12","author":"Byers P. H.","year":"1976","journal-title":"Birth Defects"},{"key":"e_1_2_1_4_1","first-page":"75","article-title":"The effect of penicillamine on the rabbit lung","volume":"105","author":"Caldwell E. J.","year":"1972","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.242.6.528"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-9113-6_36"},{"key":"e_1_2_1_7_1","first-page":"427","article-title":"Progressive airway obliteration in adults and its association with rheumatoid disease","volume":"46","author":"Geddes D. M.","year":"1977","journal-title":"Q. J. Med."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.qjmed.a067270"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1958.36"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.240.17.1870"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1152\/jappl.1971.30.4.508","article-title":"Effect of DL\u2010penicillamine on elastic properties of rat lung","volume":"30","author":"Hoffman L.","year":"1971","journal-title":"J. Appl. Physiol."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1965.91.1.35"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/jn\/98.3.303","article-title":"Relationship of maternal dietary zinc during gestation and lactation to development and zinc, iron and copper content of the postnatal rat","volume":"98","author":"Ketcheson M. R.","year":"1969","journal-title":"J. Nutr."},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","unstructured":"Kilburn K. H. R. A. Hess M.Lesser andG.Oster(1981) Perinatal death and respiratory apparatus dysgenesis due to a bis (dichloroacetyl) diamine.Teratology 1982 in press.","DOI":"10.1002\/tera.1420260207"},{"key":"e_1_2_1_15_1","first-page":"1123","article-title":"D\u2010penicillamine in rheumatoid arthritis","volume":"1","author":"Lancet","year":"1975","journal-title":"Lancet"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)92061-X"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)92681-X"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91536-5"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/S0021-9258(18)93565-9","article-title":"A defect in the intramolecular and intermolecular cross\u2010linking of collagen caused by penicillamine I. Metabolic and functional abnormalities in soft tissues","volume":"243","author":"Nimni M. E.","year":"1968","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_20_1","first-page":"220","article-title":"Collagen defect induced by penicillamine","volume":"240","author":"Nimni M. E.","year":"1972","journal-title":"Nature"},{"key":"e_1_2_1_21_1","first-page":"413","article-title":"The lung of the copper\u2010deficient rat. A model for developmental pulmonary emphysema","volume":"91","author":"O'Dell B. L.","year":"1978","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_22_1","first-page":"1300","article-title":"Pregnancy in penicillamine treated patients with Wilson's disease","volume":"293","author":"Scheinberg I. H.","year":"1975","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/279555a0"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-132-34219"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420050107"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.173.3991.62"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(67)90061-9"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(56)90066-3"},{"key":"e_1_2_1_29_1","first-page":"78","article-title":"Pregnancy in Wilson's disease","volume":"46","author":"Walshe J. M.","year":"1977","journal-title":"Q. J. Med."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(68)90037-7"},{"key":"e_1_2_1_31_1","first-page":"347","article-title":"Uterine vessel ligation in the pregnant rat 17th day of gestation\u2013midline sterile","volume":"77","author":"Wigglesworth J. S.","year":"1974","journal-title":"Am. J. Pathol."}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420260102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420260102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T05:10:45Z","timestamp":1699765845000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420260102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,8]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1982,8]]}},"alternative-id":["10.1002\/tera.1420260102"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420260102","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,8]]}}}