{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:10:57Z","timestamp":1762251057154},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T00:00:00Z","timestamp":1116460800000},"content-version":"vor","delay-in-days":8266,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1982,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>N, N<jats:sup>1<\/jats:sup>\u2010bis (dichloracetyl) diamine 1, 8\u2010octomethylenediamine (WIN 18,446) is an experimental drug which was first investigated as a male contraceptive. It is soluble in lipid solvents but not in water. The administration of 1,200 to 1,600 mg\/kg to pregnant rats on the tenth day of gestation produced multiorgan fetal malformations. Smaller doses, 400 to 800 mg\/kg, especially if divided over 2 or 3 days, caused perinatal death. Thus, 60 to 100% of offspring of rats given WIN 18,446 on the tenth and 11th days of gestation died at birth or within 4 days (Taleporos et al., 78). The present study investigated such deaths. At doses of 200 mg\/kg on day 10 or 50 mg\/kg on days 10 and 11,67% of offspring had defective or absent diaphragms, 48% had tracheobronchiomegaly with cystic lungs, and 67% had pleural hemorrhage. At doses of 100 mg\/kg given on 1 day or 25 mg\/kg each day for 2 days, 50% had tracheobronchiomegaly with cystic lungs and rudimentary acini. At lower doses (18.8 mg\/kg \u00d7 2 or 12.4 mg\/kg \u00d7 3), a majority of fetal lungs had rudimentary acini, thick septa, few capillaries, and wide cuffs of perivascular connective tissue. Thus, a chemical given during organogenesis produced dysgenesis of the respiratory apparatus. Varying the dose produced malformed lungs with persistently deficient acini which model such human lung faults as tracheobronchiomegaly (Mournier\u2010Kuhn Syndrome; Mounier\u2010Kuhn, '32), bronchiolar dysplasia (Wilson\u2010Mikity Syndrome), and perinatal death with acinar failure resembling neonatal hyaline membrane disease.<\/jats:p>","DOI":"10.1002\/tera.1420260207","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:42:27Z","timestamp":1118500947000},"page":"155-162","source":"Crossref","is-referenced-by-count":11,"title":["Perinatal death and respiratory apparatus dysgenesis due to a bis (dichloracetyl) diamine"],"prefix":"10.1002","volume":"26","author":[{"given":"Kaye H.","family":"Kilburn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rex A.","family":"Hess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marvin","family":"Lesser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Oster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01867857"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420180112"},{"key":"e_1_2_1_4_1","first-page":"35","article-title":"Tracheobronchiomegaly","volume":"91","author":"Johnson R. F.","year":"1956","journal-title":"Am. Rev. Resp. Dis."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(70)90058-4"},{"key":"e_1_2_1_6_1","first-page":"106","article-title":"Dilation de la trachie: Constations radiographiques et bronchscopiques","volume":"150","author":"Mounier\u2010Kuhn P.","year":"1932","journal-title":"Lynon Med."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(74)90001-8"},{"key":"e_1_2_1_8_1","first-page":"413","article-title":"The lung of the copper deficient rat: A model for developmental emphysema","volume":"91","author":"O'Dell B. L.","year":"1978","journal-title":"Am. J. 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