{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:28:49Z","timestamp":1760887729491},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T00:00:00Z","timestamp":1116460800000},"content-version":"vor","delay-in-days":8266,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1982,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pregnant mice (C57B1\/6JFfm) were treated with BUdR on day 9 of gestation. For doses ranging from 300 to 1,200 mg\/kg b.w. of BUdR the teratogenic effect in near\u2010term fetuses was analyzed. The findings confirm the phase and dose dependency of the induced malformations found by other authors. They also demonstrate, however, a BUdR\u2010specific induction of special malformations. For a dose of 1,200 mg\/kg of BUdR the effect on mitotic rates and the induction of chromosomal aberrations were investigated. Mitotic rates were counted in single organs as well as in total homogenized embryos. The methods are equally useful. The embryos were analyzed 3, 6, 12, and 24 hours after BUdR treatment either after homogenization or in serial sections. Decrease of mitotic rates has been found to be most remarkable at 3 and 12 hours after treatment. At 24 hours only the neural tissue showed a slight decrease of the mitotic rate. Chromosomal aberrations are induced at all times, but the highest rates are seen at 3 and 12 hours after treatment. The aberrations are of the chromatid type.<\/jats:p>","DOI":"10.1002\/tera.1420260212","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:42:27Z","timestamp":1118500947000},"page":"195-202","source":"Crossref","is-referenced-by-count":20,"title":["Teratogenic and clastogenic effects of BUdR in mice"],"prefix":"10.1002","volume":"26","author":[{"given":"J.","family":"Fr\u00e4nz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kleinebrecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"639","article-title":"Direct exposure of mouse embryonic limb\u2010buds to 5\u2010bromodeoxyuridine in vitro and its effect on chodrogenesis: Increasing resistance to the analog at successive stages of development","volume":"36","author":"Agnish N. 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