{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:47:36Z","timestamp":1762458456379},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T00:00:00Z","timestamp":1116460800000},"content-version":"vor","delay-in-days":8266,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1982,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Data in this report demonstrate a linkage between glucocorticoid\u2010induced cleft palate susceptibility and H\u20102. B10.A \u00d7 C57BL\/10F<jats:sub>1<\/jats:sub> females were backcrossed to C57BL\/10 males. Cleft palate was induced in the BC<jats:sub>1<\/jats:sub> fetuses by giving pregnant females 80 mg\/kg of dexamethasone intraperitoneally (IP) on day 12 of gestation. The H\u20102<jats:sup>a\/b<\/jats:sup> haplotype was detected on day 18 BC<jats:sub>1<\/jats:sub> fetal spleen cells with an indirect immunofluorescent labeling technique. Fetuses without antigen H\u20102K<jats:sup>k<\/jats:sup> were H\u20102<jats:sup>b\/b<\/jats:sup>. H\u20102<jats:sup>a\/b<\/jats:sup> fetuses had a cleft palate frequency of 29%; 11% of the H\u20102<jats:sup>b\/b<\/jats:sup> fetuses had cleft palate (P &lt; .01), demonstrating that the higher suceptibility to cleft palate segregates with the H\u20102<jats:sup>a<\/jats:sup> haplotype.<\/jats:p>","DOI":"10.1002\/tera.1420260214","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:42:27Z","timestamp":1118500947000},"page":"213-216","source":"Crossref","is-referenced-by-count":8,"title":["Backcross test demonstrates the linkage of glucocorticoid\u2010induced cleft palate susceptibility to H\u20102"],"prefix":"10.1002","volume":"26","author":[{"given":"Joseph J.","family":"Bonner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marvin L.","family":"Tyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01572289"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","unstructured":"Bonner J. J. andM. L.Tyan(1982a)Glucocorticoid\u2010induced cleft palate in the mouse: Evidence for two major histocompatibility complex (H\u20102) associated loci with different mechanisms (Submitted for publication).","DOI":"10.1093\/genetics\/103.2.263"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","unstructured":"Bonner J. J. andM. L.Tyan(1982b) Cleft palate susceptibility maps in two H\u20102 subregions H\u20102K to 1\u2010B and G to H\u20102D.J. of Immunogenetics in press.","DOI":"10.1111\/j.1744-313X.1982.tb00979.x"},{"key":"e_1_2_1_5_1","first-page":"771","article-title":"The increasing value of congenic mice in biomedical research","volume":"27","author":"Boyse E. A.","year":"1977","journal-title":"Lab Anim Sci"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/genetics\/53.6.1101","article-title":"Polygenic control of the teratogenicity of 5\u2010fluorouracil in mice","volume":"53","author":"Dagg C. P.","year":"1966","journal-title":"Genetics"},{"key":"e_1_2_1_7_1","first-page":"429","volume-title":"Handbook of Teratology","author":"Gaylor D. W.","year":"1978"},{"key":"e_1_2_1_8_1","volume-title":"Statistical Methods","author":"Snedecor G. W.","year":"1956"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7017931"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-158-40259"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420260214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420260214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T04:53:56Z","timestamp":1699764836000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420260214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,10]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1982,10]]}},"alternative-id":["10.1002\/tera.1420260214"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420260214","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,10]]}}}