{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:32:37Z","timestamp":1772807557933,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T00:00:00Z","timestamp":1116460800000},"content-version":"vor","delay-in-days":8143,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1983,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prenatal exposure to mirex, a chlorinated hydrocarbon insecticide, induces a high rate of perinatal death, but only a low incidence of visible abnormalities which could help to account for these deaths. This study is an attempt to determine the cause of these deaths. Pregnant rats were intubated with a moderate dose of mirex, in oil, 6 mg\/kg\/day, on days 8\u00bd\u201015\u00bd of gestation. Observations, on 78 control and 136 treated fetuses, were made on the morning before parturition was expected. Fetuses were sequentially exposed and electrocardiograms obtained with the fetus attached to the placenta and uterus. ECGs were evaluated for rate of beat, regularity of beat, PR intervals, and other features. Fetuses were examined for edema level and vitality. None of the controls were dead and none had abnormal ECGs. Of the treated group, 14% were dead, 16% had a first\u2010degree heart block, and 2% had a second\u2010degree heart block. Some (6%) had slow, feeble atrial beats only, possibly a third\u2010degree block, and appeared to be dying. The severity of the symptoms was proportional to the degree of visible edema. Most of the fetuses with little or no visible edema had normal ECGs, but the majority of the moderate to severely edematous fetuses (i.e., with a layer of subcutaneous edema across the back of 0.5 mm or more) had abnormal ECGs and\/or were either dead or dying. These data show that the effects of mirex on the fetal cardiovascular system are a major factor in inducing prenatal death.<\/jats:p>","DOI":"10.1002\/tera.1420270103","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:44:45Z","timestamp":1118501085000},"page":"7-11","source":"Crossref","is-referenced-by-count":7,"title":["The causes of perinatal death induced by prenatal exposure of rats to the pesticide, mirex. Part I: Pre\u2010parturition observations of the cardiovascular system"],"prefix":"10.1002","volume":"27","author":[{"given":"Casimer T.","family":"Grabowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris B.","family":"Payne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(79)90102-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(79)90063-8"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.23.894"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1970.10667184"},{"key":"e_1_2_1_6_1","unstructured":"Grabowski C. T.(1981a)Pesticide Effects on Prenatal Cardiovascular Physiology. EPA Technical Report No. PB81104739."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287398109530013"},{"key":"e_1_2_1_8_1","first-page":"37A","article-title":"Fetal hypoproteinemia\u2014a cause of fetal edema","volume":"23","author":"Grabowski C. T.","year":"1981","journal-title":"Teratology"},{"key":"e_1_2_1_9_1","first-page":"44A","article-title":"Functional testing for the effects of very low dose of the insecticide, mirex","volume":"25","author":"Grabowski C. T.","year":"1982","journal-title":"Teratology"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420220205"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","unstructured":"Grabowski C. T. andD. B.Payne(1983) The causes of perinatal death induced by prenatal exposure of rats to the pesticide mirex. Part II: Postnatal observations. In press J. Toxicol. and Env. 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C.","year":"1976"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-6264(76)80359-8"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(77)90033-0"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420270103","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420270103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T04:02:00Z","timestamp":1695873720000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420270103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,2]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,2]]}},"alternative-id":["10.1002\/tera.1420270103"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420270103","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,2]]}}}