{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:15:03Z","timestamp":1760188503700},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T00:00:00Z","timestamp":1117497600000},"content-version":"vor","delay-in-days":8096,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1983,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have observed dextroamphetamine sulfate to cause cardiovascular malformations in the 4\u2010day\u2010old chick embryo. Essentially all malformations were of the heart and great vessels. About one\u2010half of these were the abnormal persistence of the left fourth aortic arch. Ventricular septal defects comprised the vast majority of the other malformations. Since <jats:italic>d<\/jats:italic>\u2010amphetamine has both a direct and, more importantly, an indirect mode of alpha and beta adrenergic stimulation, three drugs were used to try to inhibit malformation production: alpha\u2010methyl\u2010p\u2010tyrosine (AMT), a catecholamine synthesis inhibitor; metoprolol, a beta<jats:sub>1<\/jats:sub> blocker; and phentolamine, an alpha blocker. When given with <jats:italic>d<\/jats:italic>\u2010amphetamine, all three drugs significantly reduced the malformation rate resulting from <jats:italic>d<\/jats:italic>\u2010amphetamine alone. We speculate that the embryonic chick is capable of responding to the alpha and\/or beta properties of dextroamphetamine sulfate. These properties may be causally related to the malformations observed.<\/jats:p>","DOI":"10.1002\/tera.1420270213","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:45:00Z","timestamp":1118501100000},"page":"253-259","source":"Crossref","is-referenced-by-count":11,"title":["Pharmacology of dextroamphetamine\u2010induced cardiovascular malformations in the chick embryo"],"prefix":"10.1002","volume":"27","author":[{"given":"Ray H.","family":"Cameron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary L.","family":"Kolesari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Kalbfleisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,31]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001490306"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.133.3450.383"},{"issue":"1","key":"e_1_2_1_4_1","first-page":"25A","article-title":"Dextroamphetamine: Embryonic cardiovascular sensitivity","volume":"25","author":"Cameron R. 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The Medical College of Wisconsin Milwaukee."},{"key":"e_1_2_1_17_1","volume-title":"Monograph 1","author":"Landauer W.","year":"1967"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0340414"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.420080504"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420010409"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(65)92892-8"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(65)90103-0"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.2535\/ofaj1936.41.4_227"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420270213","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420270213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T08:48:38Z","timestamp":1695804518000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420270213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,4]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983,4]]}},"alternative-id":["10.1002\/tera.1420270213"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420270213","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,4]]}}}