{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:53:04Z","timestamp":1789764784389,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T00:00:00Z","timestamp":1117497600000},"content-version":"vor","delay-in-days":8035,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1983,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The morphogenesis of median facial clefts induced in mice by treatment with diazo\u2010oxo\u2010norleucine (DON) was studied. Following maternal treatment with 0.4 mg\/kg DON on the 11th gestational day, 23.1% of fetuses recovered at the 18th day exhibited median facial clefts, which were characterized by a separation in the midline of normal midfacial components, i.e., the premaxilla, nasal bones, and nasal capsule. Malformed embryos could first be identified grossly 24 hr after DON administration by the presence of an abnormally wide separation between the two narrowed medial nasal processes. Evidence of cellular degeneration was observed in the mesenchyme of the nasal processes of DON\u2010treated embryos 8 and 12 hr after treatment, but little or no pyknotic debris remained at 24 hr post\u2010injection. Loss of cells due to cell death was reflected in decreased cell density observed in all areas of facial mesenchyme examined 24 hr after DON administration. It is suggested that DON\u2010induced median facial clefts may be caused by a reduction in tissue volume, particularly in the midline, or by an interference with normal facial growth resulting in increased facial width and consequent failure of merging of the medial nasal processes.<\/jats:p>","DOI":"10.1002\/tera.1420270312","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T13:10:08Z","timestamp":1118495408000},"page":"385-394","source":"Crossref","is-referenced-by-count":14,"title":["Morphogenesis of median facial clefts in mice treated with diazo\u2010oxo\u2010norleucine (DON)"],"prefix":"10.1002","volume":"27","author":[{"given":"Dorothy","family":"Burk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. W.","family":"Sadler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,31]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"173","volume-title":"Congenital Anomalies of the Face and Associated Structures","author":"Asling C. W.","year":"1961"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091930202"},{"key":"e_1_2_1_4_1","first-page":"181","article-title":"Cleft lip and jaw induced in fetal rats by vincristine","volume":"48","author":"DeMyer W.","year":"1965","journal-title":"Arch. Anat. Histol. Embryol. (Strasb.)"},{"issue":"7","key":"e_1_2_1_5_1","first-page":"155","article-title":"Median facial malformations and their implication for brain malformations","volume":"11","author":"DeMyer W.","year":"1975","journal-title":"Birth Defects"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000240405"},{"key":"e_1_2_1_7_1","first-page":"249","article-title":"Facial development in the mouse; a comparison between normal and mutant (amputated) mouse embryos","volume":"48","author":"Flint O. P.","year":"1978","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001500307"},{"key":"e_1_2_1_9_1","first-page":"355","article-title":"Limb development in mouse embryos: Protection against teratogenic effects of 6\u2010diazo\u20105\u2010oxo\u2010L\u2010norleucine (DON) in vivo and in vitro","volume":"33","author":"Greene R. M.","year":"1975","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(77)90149-5"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420140106"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420160104"},{"key":"e_1_2_1_13_1","first-page":"169","article-title":"Cleft lip induced in the rat","volume":"7","author":"Lejour M.","year":"1969","journal-title":"Cleft Palate J."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-196842010-00002"},{"key":"e_1_2_1_15_1","first-page":"37","article-title":"Regional variation of cell proliferation within the facial processes of the chick embryo: A study of the role of \u201cmerging\u201d during development","volume":"57","author":"Minkoff R.","year":"1980","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_16_1","first-page":"101","article-title":"Cell proliferation during morphogenetic change; analysis of frontonasal morphogenesis in the chick embryo employing DNA labeling indices","volume":"40","author":"Minkoff R.","year":"1977","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_17_1","first-page":"65","article-title":"Cell proliferation and cell density of mesenchyme in the maxillary process and adjacent region during facial development in the chick embryo","volume":"46","author":"Minkoff R.","year":"1978","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_18_1","first-page":"393","article-title":"Facial formation in normal and cadmium\u2010treated golden hamsters","volume":"24","author":"Mulvihill J. E.","year":"1970","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_19_1","first-page":"11","volume-title":"Congenital Anomalies of the Face and Associated Structures","author":"Patten B. M.","year":"1961"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-648350-5.50010-3"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-8933-4_4"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(70)80374-2"},{"key":"e_1_2_1_23_1","first-page":"46A","article-title":"Mechanism for in vitro inhibition of glycosaminoglycan production by diazo\u2010oxo\u2010norleucine (DON)","volume":"19","author":"Seegmiller R. E.","year":"1979","journal-title":"Teratology"},{"key":"e_1_2_1_24_1","first-page":"203","article-title":"Effects of prenatal administration of hadacidin, a cancer chemotherapeutic agent, on the development of hamster fetuses","volume":"39","author":"Shah R. M.","year":"1977","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420020102"},{"key":"e_1_2_1_26_1","volume-title":"Developmental Horizons in Human Embryos\u2014Age Groups XI to XXIII","author":"Streeter G. L.","year":"1951"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091950201"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420250114"},{"key":"e_1_2_1_29_1","first-page":"85","volume-title":"Congenital Anomalies of the Face and Associated Structures","author":"T\u00f6ndury G.","year":"1961"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(65)91192-X"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420010106"},{"key":"e_1_2_1_32_1","first-page":"A39","article-title":"Face shape and mitotic index in mice with 6\u2010aminonicotinamide\u2010induced and inherited cleft lip","volume":"9","author":"Trasler D. G.","year":"1974","journal-title":"Teratology"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-8933-4_11"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420190210"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420180108"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197812000-00006"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420270312","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420270312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T03:54:57Z","timestamp":1697687697000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420270312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,6]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1983,6]]}},"alternative-id":["10.1002\/tera.1420270312"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420270312","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,6]]}}}