{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T04:06:33Z","timestamp":1775707593891,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T00:00:00Z","timestamp":1117497600000},"content-version":"vor","delay-in-days":8035,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1983,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To determine the effects of exposure to diethylstilbestrol (DES) on the developing oviduct, timed pregnant CD\u20101 mice were treated with DES (10\u2013100 \u03bcg\/kg subcutaneous) on days 9\u201316 of gestation. Prenatal DES\u2010exposed and age\u2010matched control mice were sacrificed from day 16 of gestation to 15 weeks of age and oviductal development was compared. Following prenatal exposure to DES (100 \u03bcg\/kg), the oviduct at all ages examined was uncoiled and shorter, closely adherent to and wrapped around the ovary in an anatomical configuration similar to the fetal mouse. In addition, the demarcation between the oviduct and uterus was not readily apparent. Histological changes in the DES (100 \u03bcg\/kg) oviduct as compared with control at 10\u201315 weeks of age included a proliferation of columnar epithelium lining the lumen with gland formation extending into the underlying stroma, absence of or a reduced amount of fimbrial tissue, increased thickness of the muscular wall, and inflammatory cell infiltration. Also, as a functional test of uterotubal junction integrity, Coomassie Blue dye was injected into the uterus. The control uterotubal junction confined the fluid to the uterus. In 80% and 100% of the animals exposed prenatally to DES (10 and 100 \u03bcg\/kg, respectively), independent of the extent of the gross abnormality, the dye readily flowed into the oviduct and filled the ovarian bursa. We conclude that prenatal DES exposure can alter fetal development of the mouse oviduct, resulting in an apparent developmental arrest and functional disruption of the integrity of the uterotubal junction. The fetal like configuration of the ovary, oviduct, and uterus suggests the term developmentally arrested oviduct (DAO).<\/jats:p>","DOI":"10.1002\/tera.1420270316","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T13:10:08Z","timestamp":1118495408000},"page":"417-426","source":"Crossref","is-referenced-by-count":52,"title":["Developmentally arrested oviduct: A structural and functional defect in mice following prenatal exposure to diethylstilbestrol"],"prefix":"10.1002","volume":"27","author":[{"given":"Retha R.","family":"Newbold","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Tyrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. F.","family":"Haney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"McLachlan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,31]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)45919-4"},{"key":"e_1_2_1_3_1","first-page":"85","volume-title":"The Mammalian Oviduct","author":"Hafez E. S. E.","year":"1969"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)43814-8"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197104222841604"},{"key":"e_1_2_1_6_1","first-page":"13","article-title":"Summary of the changes in the human female genital tract as a consequence of maternal diethylstilbestrol therapy","volume":"1","author":"Herbst A. L.","year":"1976","journal-title":"J. Tox. Environ. Health Suppl."},{"key":"e_1_2_1_7_1","first-page":"1","volume-title":"Developmental Effects of Diethylstilbestrol (DES) in Pregnancy","author":"Herbst A. L.","year":"1981"},{"key":"e_1_2_1_8_1","first-page":"62","article-title":"A comparison of pregnancy experience in DES\u2010exposed and DES\u2010unexposed daughters","volume":"24","author":"Herbst A. L.","year":"1980","journal-title":"J. Reprod. Med."},{"key":"e_1_2_1_9_1","first-page":"134","volume-title":"Principles of Gynaecology","author":"Jeffcoate N.","year":"1975"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(80)90913-8"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(77)90294-0"},{"key":"e_1_2_1_12_1","first-page":"3988","article-title":"Long\u2010term effects on the female mouse genital tract associated with prenatal exposure to diethylstilbestrol","volume":"40","author":"McLachlan J. A.","year":"1980","journal-title":"Cancer Res."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)46520-9"},{"key":"e_1_2_1_14_1","first-page":"2003","article-title":"Vaginal adenosis and adenocarcinoma in mice exposed prenatally or neonatally to diethylstilbestrol","volume":"42","author":"Newbold R. R.","year":"1982","journal-title":"Cancer Res."},{"key":"e_1_2_1_15_1","first-page":"1","article-title":"Intrauterine diethylstilbestrol exposure and its consequences","volume":"101","author":"Robboy S. J.","year":"1977","journal-title":"Arch. Pathol. Lab. Med."},{"key":"e_1_2_1_16_1","first-page":"453","article-title":"Reproductive problems in the DES\u2010exposed female","volume":"55","author":"Rosenfeld D. L.","year":"1980","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)44471-7"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420270316","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420270316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T03:55:23Z","timestamp":1697687723000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420270316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,6]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1983,6]]}},"alternative-id":["10.1002\/tera.1420270316"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420270316","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,6]]}}}