{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:29:32Z","timestamp":1756992572947},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T00:00:00Z","timestamp":1116460800000},"content-version":"vor","delay-in-days":7962,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1983,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has been documented that activation of the \u03b2<jats:sub>1<\/jats:sub>\u2010adrenergic receptor mechanism is directly related to cardiovascular malformations associated with the heart and great vessels of the embryonic chick. These adrenergic receptors are believed to be present and functional in the innervated and noninnervated embryonic heart at early stages of development. The present study examined the effects of four sympathomimetic cardioactive amines on chick cardiovascular morphogenesis at Hamburger and Hamilton stage 24. Special attention was directed toward understanding dopamine teratogenicity. In order of decreasing potency at the maximum teratogenic dose (dopamine &gt; isoproterenol &gt; epinephrine &gt; norepinephrine) each drug was found capable of producing aortic arch anomalies of the third, fourth, and sixth aortic arches and ventricular septal defects (VSD). A new specific \u03b2<jats:sub>1<\/jats:sub>\u2010adrenergic antagonist, metoprolol tartrate, was employed in an attempt to lower the incidence of these cardiovascular malformations. Pretreatment with this selective \u03b2<jats:sub>1<\/jats:sub>\u2010blocker profoundly reduced the incidence of malformations within any aminetreated group. These experiments demonstrate that dopamine, as well as the other sympathomimetic amines, is a potent teratogen and most likely produces these cardiovascular malformations by primarily stimulating the \u03b2<jats:sub>1<\/jats:sub>\u2010adrenoreceptor in the embryonic chick.<\/jats:p>","DOI":"10.1002\/tera.1420280103","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:14:07Z","timestamp":1118535247000},"page":"9-14","source":"Crossref","is-referenced-by-count":15,"title":["Reduction of catecholamine\u2010induced cardiovascular malformations in the chick embryo with metoprolol"],"prefix":"10.1002","volume":"28","author":[{"given":"Randall S.","family":"Kuhlmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary L.","family":"Kolesari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Kalbfleisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600550402"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000112490"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1967.tb41229.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420160108"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420210305"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050880104"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420090211"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420120105"},{"key":"e_1_2_1_10_1","volume-title":"Physician's Desk Reference","author":"Huff B. B.","year":"1983"},{"key":"e_1_2_1_11_1","first-page":"49","article-title":"Norepinephrine and epinephrine in the embryo and embryonic heart of the chick: Uptake and subcellular distribution","volume":"159","author":"Ignarro L. J.","year":"1968","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_1_12_1","first-page":"59","article-title":"The requirement of sympathetic innervation for the active transport of norepinephrine by the heart","volume":"159","author":"Ignarro L. J.","year":"1968","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_1_13_1","first-page":"324","article-title":"Control of the neural heart rate in the chick embryo","volume":"166","author":"Jaffee O. C.","year":"1970","journal-title":"Anat. Res."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401650302"},{"key":"e_1_2_1_15_1","unstructured":"Kuhlmann R. S.(1981)An Analysis of Five Cardioactive Drugs and Their Effects Upon Cardiovascular Development in the Embryonic Chick. Ph.D. Dissertation The Medical College of Wisconsin."},{"key":"e_1_2_1_16_1","series-title":"Revised edition. Monograph 1","volume-title":"The hatchability of chicken eggs as influenced by environment and heredity","author":"Landauer W.","year":"1967"},{"key":"e_1_2_1_17_1","first-page":"405","article-title":"The time and appearance of sympathomimetic receptors in the embryonic chick heart","volume":"160","author":"Paff G. H.","year":"1968","journal-title":"Anat. Rec."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-131-34094"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0002-9378(16)34250-8","article-title":"Effects of dopamine on reproductive processes and fetal development in rats","volume":"104","author":"Samojlik E.","year":"1969","journal-title":"Am. J. Obstet. Gynecol."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700760212"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420280103","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420280103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T09:25:52Z","timestamp":1697793952000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420280103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,8]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,8]]}},"alternative-id":["10.1002\/tera.1420280103"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420280103","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,8]]}}}